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Title: Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study
Author: Mallorquí-Bagué, Núria
Lozano Madrid, María
Toledo Atucha, Estefanía
Corella Piquer, Dolores
Salas Salvadó, Jordi
Cuenca Royo, Aida
Vioque, Jesús
Romaguera, Dora
Martínez, J. Alfredo, 1957-
Wärnberg, Julia
López Miranda, José
Estruch Riba, Ramon
Bueno Cavanillas, Aurora
Alonso Gómez, Ángel M.
Tur, Josep Antoni
Tinahones, Francisco J.
Serra Majem, Lluís
Martín Sánchez, Vicente
Lapetra, José
Vázquez, Clotilde
Pintó Sala, Xavier
Vidal i Cortada, Josep
Daimiel, Lidia
Gaforio, José Juan
Matía Martín, Pilar
Ros Rahola, Emilio
Granero, Roser
Buil Cosiales, Pilar
Barragán, Rocío
Bulló, Mònica
Castañer, Olga
García de la Hera, Manoli
Yáñez, Aina M.
Abete, Itziar
García Ríos, Antonio
Ruiz Canela, Miguel
Díaz López, Andrés
Jiménez-Murcia, Susana
Martínez-González, Miguel Ángel, 1957-
Torre Fornell, Rafael de la
Fernández Aranda, Fernando
Keywords: Diabetis
Persones grans
Malalties de les persones grans
Older people
Older people diseases
Issue Date: 31-Oct-2018
Publisher: Nature Publishing Group
Abstract: This study cross-sectionally examines in the elderly population: (a) the association of type 2 diabetes with executive function (EF); (b) the effect of BMI on both type 2 diabetes and EF; (c) the association between glycaemia control and EF in type 2 diabetes. 6823 older individuals with overweight/obesity and metabolic syndrome participating in the PREDIMED-PLUS study, were assessed with a battery of cognitive tests and a medical interview. ANOVA showed a significantly worse performance on EF in type 2 diabetes vs. non-diabetic individuals. Two complementary models were displayed: (1) in the whole sample, the presence of type 2 diabetes, depressive symptoms and BMI had a direct negative effect on EF, while apnoea had an indirect negative effect; (2) in the diabetes subsample, higher illness duration was associated with worse performance in EF. Participants with type 2 diabetes and HbA1c<53 mmol/mol displayed better cognitive performance when compared to those with HbA1c≥53 mmol/mol. Our results provide a controlled comprehensive model that integrates relevant neuropsychological and physical variables in type 2 diabetes. The model suggests that, to improve treatment adherence and quality of life once diabetes has been diagnosed, cognitive decline prevention strategies need to be implemented while monitoring depressive symptoms, BMI and glycaemia control.
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It is part of: Scientific Reports, 2018, vol. 8, num. 1, p. 16128
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ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

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