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http://hdl.handle.net/2445/157517
Title: | Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study |
Author: | Mallorquí-Bagué, Núria Lozano Madrid, María Toledo Atucha, Estefanía Corella Piquer, Dolores Salas Salvadó, Jordi Cuenca Royo, Aida Vioque, Jesús Romaguera, Dora Martínez, J. Alfredo, 1957- Wärnberg, Julia López Miranda, José Estruch Riba, Ramon Bueno Cavanillas, Aurora Alonso Gómez, Ángel M. Tur, Josep Antoni Tinahones, Francisco J. Serra Majem, Lluís Martín Sánchez, Vicente Lapetra, José Vázquez, Clotilde Pintó Sala, Xavier Vidal i Cortada, Josep Daimiel, Lidia Gaforio, José J. Matía Martín, Pilar Ros Rahola, Emilio Granero, Roser Buil Cosiales, Pilar Barragán, Rocío Bulló, Mònica Castañer, Olga García de la Hera, Manuela Yáñez, Aina M. Abete, Itziar García Ríos, Antonio Ruiz Canela, Miguel Díaz López, Andrés Jiménez-Murcia, Susana Martínez-González, Miguel Ángel, 1957- Torre Fornell, Rafael de la Fernández Aranda, Fernando |
Keywords: | Diabetis Obesitat Persones grans Malalties de les persones grans Diabetes Obesity Older people Older people diseases |
Issue Date: | 31-Oct-2018 |
Publisher: | Nature Publishing Group |
Abstract: | This study cross-sectionally examines in the elderly population: (a) the association of type 2 diabetes with executive function (EF); (b) the effect of BMI on both type 2 diabetes and EF; (c) the association between glycaemia control and EF in type 2 diabetes. 6823 older individuals with overweight/obesity and metabolic syndrome participating in the PREDIMED-PLUS study, were assessed with a battery of cognitive tests and a medical interview. ANOVA showed a significantly worse performance on EF in type 2 diabetes vs. non-diabetic individuals. Two complementary models were displayed: (1) in the whole sample, the presence of type 2 diabetes, depressive symptoms and BMI had a direct negative effect on EF, while apnoea had an indirect negative effect; (2) in the diabetes subsample, higher illness duration was associated with worse performance in EF. Participants with type 2 diabetes and HbA1c<53 mmol/mol displayed better cognitive performance when compared to those with HbA1c≥53 mmol/mol. Our results provide a controlled comprehensive model that integrates relevant neuropsychological and physical variables in type 2 diabetes. The model suggests that, to improve treatment adherence and quality of life once diabetes has been diagnosed, cognitive decline prevention strategies need to be implemented while monitoring depressive symptoms, BMI and glycaemia control. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41598-018-33843-8 |
It is part of: | Scientific Reports, 2018, vol. 8, num. 1, p. 16128 |
URI: | http://hdl.handle.net/2445/157517 |
Related resource: | https://doi.org/10.1038/s41598-018-33843-8 |
ISSN: | 2045-2322 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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