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Title: Phakillestatins: an underwater unsolved puzzle
Author: Meli, Alessandra
Tedesco, Consiglia
Della Sala, Giorgio
Schettini, Rosaria
Albericio Palomera, Fernando
de Riccardis, Francesco
Izzo, Irene
Keywords: Aminoàcids
Síntesi de pèptids
Amino acids
Peptide synthesis
Issue Date: 18-Mar-2017
Publisher: MDPI
Abstract: A critical summary on the discovery of the nineteen members of the phakellistatin family (phakellistatin 1-19), cytotoxic proline‐rich cyclopeptides of marine origin, is reported. Isolation, structural elucidation, and biological properties of the various‐sized natural macrocycles are described, along with the total syntheses and the enigmatic issues of the cytotoxic activity reproducibility.
Note: Reproducció del document publicat a:
It is part of: Marine Drugs, 2017, vol. 15, num. 3, p. 78
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ISSN: 1660-3397
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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