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Title: PPARβ/δ: A Key Therapeutic Target in Metabolic Disorders
Author: Palomer Tarridas, Francesc Xavier
Barroso Fernández, Emma
Pizarro Delgado, Javier
Peña, Lucía
Botteri, Gaia
Zarei, Mohammad
Aguilar, David
Montori Grau, Marta
Vázquez Carrera, Manuel
Keywords: Homeòstasi
Metabolisme cel·lular
Cell metabolism
Issue Date: 20-Mar-2018
Publisher: MDPI
Abstract: Research in recent years on peroxisome proliferator-activated receptor (PPAR)β/δ indicates that it plays a key role in the maintenance of energy homeostasis, both at the cellular level and within the organism as a whole. PPARβ/δ activation might help prevent the development of metabolic disorders, including obesity, dyslipidaemia, type 2 diabetes mellitus and non-alcoholic fatty liver disease. This review highlights research findings on the PPARβ/δ regulation of energy metabolism and the development of diseases related to altered cellular and body metabolism. It also describes the potential of the pharmacological activation of PPARβ/δ as a treatment for human metabolic disorders
Note: Reproducció del document publicat a:
It is part of: International Journal of Molecular Sciences, 2018, vol. 19, num. 3, p. 913
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ISSN: 1661-6596
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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