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Title: In-vitro study of hierarchical structures: Anodic oxidation and alkaline treatments onto highly rough titanium cold spray coatings for biomedical applications
Author: Martín Vilardell, Anna
Cinca i Luis, Núria
Garcia Giralt, Natàlia
Muller Jevenois, Carlos
Dosta Parras, Sergi
Sarret i Pons, Maria
García Cano, Irene
Nogués Solán, Xavier
Guilemany, J. M. (José María)
Keywords: Revestiments
Materials biomèdics
Biomedical materials
Issue Date: 24-May-2018
Publisher: Elsevier
Abstract: Hierarchical structures were obtained applying two different nanotexturing surface treatments onto highly rough commercial pure titanium coatings by cold spray: (i) anodic oxidation and (ii) alkaline treatments. An extended surface characterization in terms of topography, composition, and wettability has been performed to understand how those parameters affect to cell response. Primary human osteoblasts extracted from knee were seeded onto the as-sprayed titanium surface before and after the nanotexturing treatments. Cell viability was tested by using MTS and LIVE/DEAD assays, as well as osteoblasts differentiation by alkaline phosphatase (ALP) quantification at 3 and 10 days of cell culture. The combination of micro-/nano-roughness results in a significantly increase of cell proliferation, as well as cell differentiation after 10 days of cell culture in comparison with the non-treated coatings.
Note: Versió postprint del document publicat a:
It is part of: Materials Science and Engineering: C, 2018, vol. 91, p. 589-596
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ISSN: 0928-4931
Appears in Collections:Articles publicats en revistes (Ciència dels Materials i Química Física)

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