Please use this identifier to cite or link to this item:
Title: Lessons on differential neuronal-death-vulnerability from familial cases of Parkinson's and Alzheimer's diseases
Author: Franco Fernández, Rafael
Navarro Brugal, Gemma
Martínez-Pinilla, Eva
Keywords: Malaltia de Parkinson
Malaltia d'Alzheimer
Parkinson's disease
Alzheimer's disease
Issue Date: 4-Jul-2019
Publisher: MDPI
Abstract: The main risk of Alzheimer's disease (AD) and Parkinson's disease (PD), the two most common neurodegenerative pathologies, is aging. In contrast to sporadic cases, whose symptoms appear at >60 years of age, familial PD or familial AD affects younger individuals. Finding early biological markers of these diseases as well as efficacious treatments for both symptom relief and delaying disease progression are of paramount relevance. Familial early-onset PD/AD are due to genetic factors, sometimes a single mutation in a given gene. Both diseases have neuronal loss and abnormal accumulations of specific proteins in common, but in different brain regions. Despite shared features, the mechanisms underlying the pathophysiological processes are not known. This review aims at finding, among the genetic-associated cases of PD and AD, common trends that could be of interest to discover reliable biomarkers and efficacious therapies, especially those aimed at affording neuroprotection, i.e., the prevention of neuronal death.
Note: Reproducció del document publicat a:
It is part of: International Journal of Molecular Sciences, 2019, vol. 20, num. 13
Related resource:
ISSN: 1661-6596
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

Files in This Item:
File Description SizeFormat 
696852.pdf1.9 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons