Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/158146
Title: Effects of combined d-fagomine and omega-3 PUFAs on gut microbiota subpopulations and diabetes risk factors in rats fed a high-fat diet
Author: Hereu, Mercè
Ramos Romero, Sara
Busquets, Cristina
Atienza, Lidia
Amézqueta, Susana
Miralles-Pérez, Bernat
Nogués, M. Rosa
Méndez, Lucía
Medina, Isabel
Torres, Josep Lluís
Keywords: Microbiota intestinal
Diabetis
Gastrointestinal microbiome
Diabetes
Issue Date: 1-Sep-2019
Publisher: Nature Publishing Group
Abstract: Food contains bioactive compounds that may prevent changes in gut microbiota associated with Westernized diets. The aim of this study is to explore the possible additive effects of d-fagomine and ω-3 PUFAs (EPA/DHA 1:1) on gut microbiota and related risk factors during early stages in the development of fat-induced pre-diabetes. Male Sprague Dawley (SD) rats were fed a standard diet, or a high-fat (HF) diet supplemented with d-fagomine, EPA/DHA 1:1, a combination of both, or neither, for 24 weeks. The variables measured were fasting glucose and glucose tolerance, plasma insulin, liver inflammation, fecal/cecal gut bacterial subgroups and short-chain fatty acids (SCFAs). The animals supplemented with d-fagomine alone and in combination with ω-3 PUFAs accumulated less fat than those in the non-supplemented HF group and those given only ω-3 PUFAs. The combined supplements attenuated the high-fat-induced incipient insulin resistance (IR), and liver inflammation, while increasing the cecal content, the Bacteroidetes:Firmicutes ratio and the populations of Bifidobacteriales. The functional effects of the combination of d-fagomine and EPA/DHA 1:1 against gut dysbiosis and the very early metabolic alterations induced by a high-fat diet are mainly those of d-fagomine complemented by the anti-inflammatory action of ω-3 PUFAs.
Note: Reproducció del document publicat a: https://doi.org/10.1038/s41598-019-52678-5
It is part of: Scientific Reports, 2019, vol. 9, p. 16628
URI: http://hdl.handle.net/2445/158146
Related resource: https://doi.org/10.1038/s41598-019-52678-5
ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Enginyeria Química i Química Analítica)
Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)

Files in This Item:
File Description SizeFormat 
695830.pdf1.91 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons