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Title: Dlk1 expression relates to visceral fat expansion and insulin resistance in male and female rats with postnatal catch-up growth
Author: Carreras Badosa, Gemma
Remesar Betlloch, Xavier
Prats Puig, Anna
Xargay i Torrent, Sílvia
Lizarraga Mollinedo, Esther
Zegher, Francis de
Ibáñez, Lourdes
Bassols, Judit
López Bermejo, Abel
Keywords: Medicina prenatal
Trastorns del metabolisme
Rates (Animals de laboratori)
Prenatal medicine
Disorders of metabolism
Rats as laboratory animals
Issue Date: 15-May-2019
Publisher: Nature Publishing Group
Abstract: Background: Although prenatal and postnatal programming of metabolic diseases in adulthood is well established, the mechanims underpinning metabolic programming are not. DLK1, a key regulator of fetal development, inhibits adipocyte differentiation and restricts fetal growth. Methods: Assess Dlk1 expression in Wistar rat model of catch-up growth following intrauterine restriction. Dams fed ad libitum deliverd control pups (C) and dams on a 50% calorie-restricted diet delivered pups with low birth weight (R). Restricted offspring fed a standard rat chow showd catch-up growth (R/C) but those kept on a calorie-restricted diet did not (R/R). Results: Decreased Dlk1 expression was observed in adipose tissue and skeletal muscle of R/C pups along with excessive visceral fat accumulation, decreased circulating adiponectin, increased triglycerides and HOMA-IR (from p<0.05 to p<0.001). Moreover, in R/C pups, the reduced Dlk1 expression in adipose tissue and skeletal muscle correlated with visceral fat (r= -0.820; p<0.0001) and HOMA-IR (r= -0.745; p=0.002). Conclusions: Decreased Dlk1 expression relates to visceral fat expansion and insulin resistance in a rat model of catch-up growth following prenatal growth restriction. Modulation of Dlk1 expression could be among the targets of the early prevention of fetal preogramming of adult metabolic disorders.
Note: Versió postprint del document publicat a:
It is part of: Pediatric Research, 2019, vol. 86, p. 195-201
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ISSN: 0031-3998
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)

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