Please use this identifier to cite or link to this item:
Title: Sulfonamide linked ciprofloxacin derivatives as a novel class of inhibitors of jack bean urease. Synthesis of Kinetic mechanism and Bioinformatics
Author: Ali Channar, Pervaiz
Saeed, Aamer
Albericio Palomera, Fernando
Ali Larik, F.
Abbas, Qamar
Hassan, Mubashir
Raza, Hussain
Seo, Sung-Yum
Keywords: Disseny de medicaments
Drug design
Issue Date: 16-Aug-2017
Publisher: MDPI
Abstract: Sulfonamide derivatives serve as an important building blocks in the drug design discovery and development (4D) process. Ciprofloxacin-, sulfadiazine- and amantadine-based sulfonamides were synthesized as potent inhibitors of jack bean urease and free radical scavengers. Molecular diversity was explored and electronic factors were also examined. All 24 synthesized compounds exhibited excellent potential against urease enzyme. Compound 3e (IC50 = 0.081 ± 0.003 µM), 6a (IC50 = 0.0022 ± 0.0002 µM), 9e (IC50 = 0.0250 ± 0.0007 µM) and 12d (IC50 = 0.0266 ± 0.0021 µM) were found to be the lead compounds compared to standard (thiourea, IC50 = 17.814 ± 0.096 µM). Molecular docking studies were performed to delineate the binding affinity of the molecules and a kinetic mechanism of enzyme inhibition was propounded. Compounds 3e, 6a and 12d exhibited a mixed type of inhibition, while derivative 9e revealed a non-competitive mode of inhibition. Compounds 12a, 12b, 12d, 12e and 12f showed excellent radical scavenging potency in comparison to the reference drug vitamin C.
Note: Reproducció del document publicat a:
It is part of: Molecules, 2017, vol. 22, num. 8, p. 1352
Related resource:
ISSN: 1420-3049
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

Files in This Item:
File Description SizeFormat 
681064.pdf2.02 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons