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http://hdl.handle.net/2445/158592
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DC Field | Value | Language |
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dc.contributor.author | Mariño-Sánchez, Franklin Santiago | - |
dc.contributor.author | Valls Mateus, Meritxell | - |
dc.contributor.author | Fragola, C. | - |
dc.contributor.author | Santos, G. de los | - |
dc.contributor.author | Aguirre, A. | - |
dc.contributor.author | Alonso, J. | - |
dc.contributor.author | Valero, J. | - |
dc.contributor.author | Santamaría, A. | - |
dc.contributor.author | Rojas Lechuga, M. J. | - |
dc.contributor.author | Cobeta, I. | - |
dc.contributor.author | Alobid, Isam | - |
dc.contributor.author | Mullol i Miret, Joaquim | - |
dc.date.accessioned | 2020-05-04T17:20:46Z | - |
dc.date.available | 2020-05-04T17:20:46Z | - |
dc.date.issued | 2019-01-01 | - |
dc.identifier.uri | http://hdl.handle.net/2445/158592 | - |
dc.description.abstract | Background: Few odour tests have been created for children. Objectives: The aim of the present study was to develop and validate a simple and quick olfactory test, suitable for the evaluation of odour identification and threshold in a Spanish paediatric population, the paediatric Barcelona Olfactory Test-6 (pBOT-6).The pBOT-6 consisted in a set of 6 odorants for a forced-choice identification test (IT), and a 6 dilutions phenyl ethyl alcohol geometric series for the threshold test (TT). The pBOT-6 was compared with the U-sniff test (a validated international paediatric smell test) in 131 Spanish healthy volunteers aged 6-17 years. A Bland-Altman plot was used to determine the agreement between two tests. Reliability was analyzed in fifteenvolunteers using the intraclass correlation coefficient (ICC). Normative data was obtained and 8 children diagnosed with subjective smell loss were tested for validation.Bland-Altman analysis demonstrated a minimal bias of -1.71% with upper and lower limit of agreement of -31.1% and 27.6%, respectively. The ICC was 0.83 (95% CI 0.6-0.96) for the IT and 0.73 (95% CI 0.36-0.9) for the TT, showing excellent and good consistency between measurements over time. Mean pBOT-6 scores were significantly higher in healthy volunteers compared with patients with smell loss. Discrimination between normosmia and smell loss was achieved with a sensitivity of 96.9% and a specificity of 100%.The pBOT-6 offers an effectiveand fast method useful in clinical routine to distinguish, with high sensitivity and specificity, between paediatric patients with normosmia and those with smell dysfunction. | - |
dc.format.extent | 24 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Esmon Publicidad S.A. | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.18176/jiaci.0451 | - |
dc.relation.ispartof | Journal of Investigational Allergology and Clinical Immunology, 2019, vol. 30, num. 6 | - |
dc.relation.uri | https://doi.org/10.18176/jiaci.0451 | - |
dc.rights | (c) Esmon Publicidad S.A., 2019 | - |
dc.source | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) | - |
dc.subject.classification | Infants | - |
dc.subject.classification | Olfactometria | - |
dc.subject.other | Children | - |
dc.subject.other | Olfactometry | - |
dc.title | Paediatric Barcelona Olfactory Test-6 (pBOT-6): Validation of a Combined Odour Identification and Threshold Screening Test in Healthy Spanish Children and Adolescents | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.date.updated | 2020-02-28T10:37:41Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 5882134 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
Files in This Item:
File | Description | Size | Format | |
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12474_5882134_pmid31530512.pdf | 1.3 MB | Adobe PDF | View/Open |
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