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http://hdl.handle.net/2445/158701
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DC Field | Value | Language |
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dc.contributor.author | Bosch Hereu, Lluís | - |
dc.contributor.author | Delelis, Olivier | - |
dc.contributor.author | Subra, Frédéric | - |
dc.contributor.author | Deprez, Eric | - |
dc.contributor.author | Witvrow, Myriam | - |
dc.contributor.author | Vilarrasa i Llorens, Jaume | - |
dc.date.accessioned | 2020-05-05T09:21:37Z | - |
dc.date.available | 2020-05-05T09:21:37Z | - |
dc.date.issued | 2012-03-01 | - |
dc.identifier.issn | 0040-4039 | - |
dc.identifier.uri | http://hdl.handle.net/2445/158701 | - |
dc.description.abstract | N3 of thymidine and of 3′-azido-3′-deoxythymidine (AZT) has been linked to a tetrazole ring by condensation of nucleoside-derived 2-oxonitriles with the lithium salt of 5-acetyl-1-(4-fluorobenzyl)tetrazole (obtained by a 'click' reaction). 4-Acetyl-1,2,3-triazole, also prepared by a Cu-catalysed cycloaddition, has been similarly linked. A route for the conjugation of NRTIs with pharmacophoric elements of integrase inhibitors (INIs) has thus been disclosed. | - |
dc.format.extent | 5 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier Ltd | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.tetlet.2011.11.079 | - |
dc.relation.ispartof | Tetrahedron Letters, 2012, vol. 53, num. 3, p. 514-518 | - |
dc.relation.uri | https://doi.org/10.1016/j.tetlet.2011.11.079 | - |
dc.rights | (c) Elsevier Ltd, 2012 | - |
dc.source | Articles publicats en revistes (Química Inorgànica i Orgànica) | - |
dc.subject.classification | VIH (Virus) | - |
dc.subject.classification | Inhibidors de la integrasa | - |
dc.subject.classification | Integrase inhibitors | - |
dc.subject.other | HIV (Viruses) | - |
dc.title | Thymidine- and AZT-linked 5-(1,3-dioxoalkyl)tetrazoles and 4-(1,3-dioxoalkyl)-1,2,3-triazoles | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 611183 | - |
dc.date.updated | 2020-05-05T09:21:37Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
Files in This Item:
File | Description | Size | Format | |
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611183.pdf | 548.21 kB | Adobe PDF | View/Open |
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