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http://hdl.handle.net/2445/158715
Title: | Phytosterolemia associated with parenteral nutrition administration in adult patients |
Author: | Llop Talaverón, Josep Manuel Leiva Badosa, Elisabet Novak, Ana Rigo Bonnin, Raúl Ticó Grau, Josep R. Suñé i Negre, Josep M. (Josep Maria) Suárez Lledó, Ana Lozano Andreu, Toni Badía Tahull, Maria |
Keywords: | Lípids de la sang Fitosterols Blood lipids Phytosterols |
Issue Date: | 20-Feb-2020 |
Publisher: | Cambridge University Press (CUP) |
Abstract: | Vegetable lipid emulsions (LE) contain non-declared phytosterols (PS). We aimed to determine PS content depending on the brand and LE batch; and in adult hospitalized patients treated with parenteral nutrition (PN), to establish the association between plasma and administered PS. I. LE study: Totals and fractions of PS in 3-4 non-consecutive batches from 6 LE were analysed. II. Patient study: randomized, double-blind study of patients with at least 7 previous days of PN with 0.8 g/kg/day of an olive/soybean LE, were randomized (Day 0) 1:1 to olive/soybean (O/S) or 100% fish oil (FO) at a dose of 0.4 g/kg/day for 7 days (Day 7). Plasma PS, its fractions, total cholesterol on Days 0 and 7, their clearance, and their association with PS administered by LE were studied. In part I. LE study: differences were found in the total PS, their fractions and cholesterol among different LE brands and batches. Exclusive soybean LE had the highest content of PS (422.36 ± 130.46 μg/mL). II. Patient study: 19 patients were included. In the O/S group, PS levels were maintained (1.11±6.98 μg/mL) from Day 0 to 7, while in the FO group, significant decreases were seen in total PS (-6.21±4.73 μg/mL) and their fractions, except for campesterol and stigmasterol. Plasma PS on Day 7 were significantly associated with PS administered (R2=0.443). PS content in different LE brands had great variability. PS administered during PN resulted in accumulation and could be prevented with the exclusive administration of FO LE. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1017/S0007114520000574 |
It is part of: | British Journal of Nutrition, 2020, vol. 123, num. 12, p. 1365-1372 |
URI: | http://hdl.handle.net/2445/158715 |
Related resource: | https://doi.org/10.1017/S0007114520000574 |
Appears in Collections: | Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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