Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/158757
Title: The Application of Statins in the Regeneration of Bone Defects. Systematic Review and Meta-Analysis
Author: Roca Millan, Elisabet
Gonzalez Navarro, Beatriz
Izquierdo-Gómez, Keila
Marí Roig, Antonio
Jané Salas, Enric
López López, José, 1958-
Velasco Ortega, Eugenio
Keywords: Creixement dels ossos
Farmacologia
Medicina regenerativa
Bones growth
Pharmacology
Regenerative medicine
Issue Date: 16-Sep-2019
Publisher: MDPI
Abstract: This systematic review aims to analyze the effect of the local application of statins in the regeneration of non-periodontal bone defects. A systematic study was conducted with the Pubmed/Medline, Embase, Cochrane Library and Scielo databases for in vivo animal studies published up to and including February 2019. Fifteen articles were included in the analysis. The local application of the drug increased the percentage of new bone formation, bone density, bone healing, bone morphogenetic protein 2, vascular endothelial growth factor, progenitor endothelial cells and osteocalcin. Meta-analyses showed a statistically significant increase in the percentage of new bone formation when animals were treated with local statins, in contrast to the no introduction of filling material or the introduction of polylactic acid, both in an early (4-6 weeks) and in a late period (12 weeks) (mean difference 39.5%, 95% confidence interval: 22.2-56.9, p <0.001; and mean difference 43.3%, 95% confidence interval: 33.6-52.9, p < 0.001, respectively). Basing on the animal model, the local application of statins promotes the healing of critical bone size defects due to its apparent osteogenic and angiogenic effects. However, given the few studies and their heterogenicity, the results should be taken cautiously, and further pilot studies are necessary, with radiological and histological evaluations to translate these results to humans and establish statins' effect.
Note: Reproducció del document publicat a: https://doi.org/10.3390/ma12182992
It is part of: Materials, 2019, vol. 12, num. 18, p. 2992
URI: http://hdl.handle.net/2445/158757
Related resource: https://doi.org/10.3390/ma12182992
ISSN: 1996-1944
Appears in Collections:Articles publicats en revistes (Odontoestomatologia)

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