Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/159039
Title: Differential distribution fo the wlaN and cgtB genes, associated with Guillain-Barré syndrome, in Campylobacter jejuni isolates from humans, broiler chickens, and wild birds
Author: Guirado, Pedro
Paytubi Casabona, Sònia
Miró, Elisenda
Iglesias-Torrens, Yaidelis
Navarro, Ferran
Cerdà-Cuéllar, Marta
Stephan-Otto Attolini, Camille
Balsalobre Parra, Carlos
Madrid Xufré, Cristina
Keywords: Malalties del sistema nerviós
Malalties autoimmunitàries
Nervous system Diseases
Autoimmune diseases
Issue Date: 26-Feb-2020
Publisher: MDPI
Abstract: Campylobacter jejuni causes campylobacteriosis, a bacterial gastroenteritis with high incidence worldwide. Moreover, C. jejuni infection can trigger the polyneuropathic disorder denominated Guillain-Barré syndrome (GBS). The C. jejuni strains that can elicit GBS carry either wlaN or cgtB, coding both genes for a β-1,3-galactosyltransferase enzyme that is required for the production of sialylated lipooligosaccharide (LOSSIAL). We described a differential prevalence of the genes wlaN and cgtB in C. jejuni isolates from three different ecological niches: humans, broiler chickens, and wild birds. The distribution of both genes, which is similar between broiler chicken and human isolates and distinct when compared to the wild bird isolates, suggests a host-dependent distribution. Moreover, the prevalence of the wlaN and cgtB genes seems to be restricted to some clonal complexes. Gene sequencing identified the presence of new variants of the G- homopolymeric tract within the wlaN gene. Furthermore, we detected two variants of a G rich region within the cgtBgene, suggesting that, similarly to wlaN, the G-tract in the cgtB gene mediates the phase variation control of cgtB expression. Caco-2 cell invasion assays indicate that there is no evident correlation between the production of LOSSIAL and the ability to invade eukaryotic cells.
Note: Reproducció del document publicat a: https://doi.org/10.3390/microorganisms8030325
It is part of: Microorganisms, 2020, vol. 8, p. 325
URI: http://hdl.handle.net/2445/159039
Related resource: https://doi.org/10.3390/microorganisms8030325
ISSN: 2076-2607
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)

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