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Title: Preparation of tetrahydro-1H-xanthen-1-one and chromen-1-one derivatives via a Morita-Baylis-Hillman/oxa-Michael/elimination cascade
Author: Rodrigues, Jr., Manoel T.
Santos, Hugo
Zeoly, Lucas A.
Simoni, Deborah A.
Moyano i Baldoire, Albert
Coelho, Fernando
Keywords: Catàlisi
Química de l'aigua
Water chemistry
Issue Date: 21-Feb-2020
Publisher: Michigan Publishing
Abstract: The Morita-Baylis-Hillman (MBH) reaction is a carbon-carbon bond forming transformation between an electrophile, typically an aldehyde, and an activated olefin. MBH adducts obtained from 2-hydroxy- benzaldehydes and cyclic enones are potential substrates for the synthesis of xanthenone and chromenone derivatives. In this work, we investigated conditions to obtain tetrahydro-1H-xanthen-1-ones and chromen- 1-ones directly via a Morita-Baylis-Hillman/oxa-Michael/elimination cascade catalyzed by a bifunctional, bicyclic imidazolyl alcohol (BIA), which proved to be an effective catalyst for this transformation. The reactions were performed at room temperature in water to give the products in 10-74 % yield.
Note: Reproducció del document publicat a:
It is part of: Arkivoc, 2020, vol. 2020, num. part ii, p. 77-88
Related resource:
ISSN: 1551-7012
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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