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Title: Role of a Polyphenol-Rich Dietary Pattern in the Modulation of Intestinal Permeability in Older Subjects: The MaPLE Study
Author: Bernard, Stefano
Bo', Cristian Del
Guglielmetti, Simone
Cherubini, Antonio
Kroon, Paul A.
Kirkup, Benjamin
Hidalgo Liberona, Nicole
Peron, Gregorio
González Domínguez, Raúl
Andrés Lacueva, Ma. Cristina
Riso, Patrizia
Keywords: Malalties cròniques
Persones grans
Malalties inflamatòries intestinals
Chronic diseases
Older people
Inflammatory bowel diseases
Issue Date: 16-Aug-2019
Publisher: MDPI
Abstract: The inevitable rise of the proportion of people aged >65 years worldwide is paralleled by an increased burden of chronic diseases often associated with low-grade systemic inflammation. Recent findings suggest a link between inflammation and intestinal permeability (IP), a condition characterized by an impairment of intestinal barrier function which enables the translocation of dietary and bacterial factors into the blood activating the host immune system [1,2]. Dietary components can be significant modulators of inflammation and IP, and can also affect the intestinal microbial ecosystem. In the context of a diet-microbiota-IP axis in older subjects, dietary bioactives such as polyphenols may play a significant protective role due to their widely reported antioxidant and immunomodulatory properties and potential to regulate IP [3-6].
Note: Reproducció del document publicat a:
It is part of: MDPI Proceedings, 2019, vol. 11, num. 8
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ISSN: 2504-3900
Appears in Collections:Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
Articles publicats en revistes (Institut de Recerca en Nutrició i Seguretat Alimentària (INSA·UB))

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