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http://hdl.handle.net/2445/159770
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DC Field | Value | Language |
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dc.contributor.author | Ruiz García, Marta | - |
dc.contributor.author | Pérez Lozano, Pilar | - |
dc.contributor.author | Mercadé Frutos, Débora | - |
dc.contributor.author | Nardi Ricart, Anna | - |
dc.contributor.author | Suñé Pou, Marc | - |
dc.contributor.author | Cano Sarabia, Mary | - |
dc.contributor.author | García Jimeno, Sonia | - |
dc.contributor.author | Suñé i Negre, Josep M. (Josep Maria) | - |
dc.contributor.author | Maspoch, Daniel | - |
dc.contributor.author | García Montoya, Encarna | - |
dc.date.accessioned | 2020-05-12T14:06:09Z | - |
dc.date.available | 2020-05-12T14:06:09Z | - |
dc.date.issued | 2019-11-26 | - |
dc.identifier.issn | 2470-1343 | - |
dc.identifier.uri | http://hdl.handle.net/2445/159770 | - |
dc.description.abstract | A high-performance liquid chromatography (HPLC) method was developed to simultaneously quantify three widely used active substances such as coenzyme Q10, phosphatidylserine, and vitamin C. This new method optimizes current timing and costs in the analyses of these three active substances. Additionally, since the analyzed compounds were encapsulated on a cutting-edge liposomal formulation, further processing was necessary to be developed prior to HPLC analyses. The technique was studied and adequately validated in accordance with the guidelines of the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) regarding selectivity, linearity, accuracy, precision, and robustness. After data treatment of results, linear regressions for all active substances showed an optimal linearity with a correlation coefficient of >0.999 in the concentration range between 70 to 130% of the liposomal formulation and less than a 3% relative standard deviation (RSD) in accuracy and precision. | - |
dc.format.extent | 6 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Chemical Society | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1021/acsomega.9b02456 | - |
dc.relation.ispartof | ACS Omega , 2019, vol. 4, num. 22, p. 19710-19715 | - |
dc.relation.uri | https://doi.org/10.1021/acsomega.9b02456 | - |
dc.rights | (c) American Chemical Society, 2019 | - |
dc.source | Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) | - |
dc.subject.classification | Cromatografia de líquids | - |
dc.subject.classification | Coenzims | - |
dc.subject.other | Liquid chromatography | - |
dc.subject.other | Coenzymes | - |
dc.title | Development and Validation of a New High-Performance Liquid Chromatography Method for the Simultaneous Quantification of Coenzyme Q10, Phosphatidylserine, and Vitamin C from a Cutting-Edge Liposomal Vehiculization | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 694683 | - |
dc.date.updated | 2020-05-12T14:06:09Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31788602 | - |
Appears in Collections: | Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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694683.pdf | 920.62 kB | Adobe PDF | View/Open |
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