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Title: Genetic variants of innate immunity receptors are associated with mortality in cirrhotic patients with bacterial infection
Author: Schaapman, Jelte J.
Amorós, Àlex
Reijden, Johan J. van der
Laleman, Wim
Zeuzem, Stefan
Bañares, Rafael
Jalan, Rajiv
Arroyo, Vicente
Clària i Enrich, Joan
Verspaget, Hein W.
Coenraad, Minneke J.
Keywords: Mortalitat
Malalties bacterianes
Cirrosi hepàtica
Genètica mèdica
Bacterial diseases
Hepatic cirrhosis
Medical genetics
Issue Date: Mar-2020
Publisher: John Wiley & Sons
Abstract: BACKGROUND & AIMS: Acute-on-chronic liver failure (ACLF) is characterized by acute decompensation of cirrhosis (AD), organ failure(s) and high risk of short-term mortality with bacterial infection frequently as precipitating event. Innate immune pattern recognition receptors and members of the lectin pathway of complement activation are crucial to the innate immune response to pathogens. The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) of innate immune components are associated with the occurrence of bacterial infections or mortality in patients with cirrhosis hospitalized for AD or ACLF. METHODS: Twenty-one innate immunity SNPs with known functional implications were genotyped in 826 AD/ACLF patients included in the CANONIC study. Associations between baseline characteristics of the patients, the occurrence of bacterial infections and survival rate at 90 days of follow-up in relation to the innate immunity genetic variants were analysed. RESULTS: The NOD2-G908R genetic variant was associated with mortality (HR 2.25, P = .004) independently of age and MELD Score. This association was also found in a predefined subgroup analysis in patients with bacterial infections (HR 2.78, P < .001) along with MBL_Yx (HR 1.72, P = .008) and MASP2_371 (HR 1.67, P = .012) genetic variants. None of the analysed SNPs were significantly associated with the occurrence of acute bacterial infections or spontaneous bacterial peritonitis in particular. CONCLUSIONS: Innate immune system-specific NOD2-G908R, MBL_Yx and MASP2_371 genetic variants were independently associated with increased risk of short-term mortality in AD/ACLF patients with bacterial infection.
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It is part of: Liver International, 2020, vol. 40, num. 3, p. 646-653
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ISSN: 1478-3223
Appears in Collections:Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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