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http://hdl.handle.net/2445/159963
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DC Field | Value | Language |
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dc.contributor.author | Montañez, Eloi | - |
dc.contributor.author | Ussar, Siegfried | - |
dc.contributor.author | Schifferer, Martina | - |
dc.contributor.author | Bösl, Michael | - |
dc.contributor.author | Zent, Roy | - |
dc.contributor.author | Moser, Markus | - |
dc.contributor.author | Fässler, Reinhard | - |
dc.date.accessioned | 2020-05-13T10:30:29Z | - |
dc.date.available | 2020-05-13T10:30:29Z | - |
dc.date.issued | 2008-05-15 | - |
dc.identifier.issn | 0890-9369 | - |
dc.identifier.uri | http://hdl.handle.net/2445/159963 | - |
dc.description.abstract | Control of integrin activation is required for cell adhesion and ligand-induced signaling. Here we report that loss of the focal adhesion protein Kindlin-2 in mice results in peri-implantation lethality caused by severe detachment of the endoderm and epiblast from the basement membrane. We found that Kindlin-2-deficient cells were unable to activate their integrins and that Kindlin-2 is required for talin-induced integrin activation. Furthermore, we demonstrate that Kindlin-2 is required for integrin outside-in signaling to enable firm adhesion and spreading. Our findings provide evidence that Kindlin-2 is a novel and essential element of bidirectional integrin signaling. | - |
dc.format.extent | 6 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Cold Spring Harbor Laboratory Press | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1101/gad.469408 | - |
dc.relation.ispartof | Genes & Development, 2008, vol. 22, num. 10, p. 1325-1330 | - |
dc.relation.uri | https://doi.org/10.1101/gad.469408 | - |
dc.rights | (c) Montañez, Eloi et al., 2008 | - |
dc.source | Articles publicats en revistes (Ciències Fisiològiques) | - |
dc.subject.classification | Proteïnes citosquelètiques | - |
dc.subject.classification | Integrines | - |
dc.subject.classification | Metabolisme | - |
dc.subject.other | Cytoskeletal proteins | - |
dc.subject.other | Integrins | - |
dc.subject.other | Metabolism | - |
dc.title | Kindlin-2 controls bidirectional signaling of integrins. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 699438 | - |
dc.date.updated | 2020-05-13T10:30:29Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 18483218 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) |
Files in This Item:
File | Description | Size | Format | |
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699438.pdf | 498.35 kB | Adobe PDF | View/Open |
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