Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/159988
Title: | Formation of nanoemulsion containing ibuprofen by PIC method for topical delivery |
Author: | Salim, Norazlinaliza García Celma, Ma José Escribano Ferrer, Elvira Nolla, Jordi Llinàs, Meritxell Basri, Mahiran Solans Marsà, Conxita Esquena, Jordi Tadros, Tharwat F. |
Keywords: | Nanofluids Antiinflamatoris no esteroïdals Nanofluids Nonsteroidal anti-inflammatory agents |
Issue Date: | 1-Jan-2018 |
Publisher: | Elsevier |
Abstract: | This study reports the formation of nanoemulsions from palm-kernel oil esters (PKOE)/Cremophor EL/water systems intended for topical administration of a non-steroidal anti-inflammatory drug, ibuprofen. Nanoemulsions containing 2% ibuprofen, various oil:surfactant ratios (10:90, 20:80 and 30:70) and 80% of water were selected from the ternary system of PKOE/Cremophor EL/water and prepared by the phase inversion composition (PIC) method. The characterization of the nanoemulsions such as droplet size, polydispersity index, zeta potential, stability and the permeation of ibuprofen from nanoemulsions were evaluated. The prepared nanoemulsions exhibited good stability without any phase separation, sedimentation or creaming for the period of tested experimental time (6 months). The permeation study of ibuprofen was performed on Franz type-diffusion cells through human abdominal skin. The median values of the fluxes obtained as well as the median of the percentage of permeated amount at 24h were not statistically different. The mean profiles of permeated ibuprofen versus time from PKOE was greater (p < 0.05) than those obtained from Miglyol 812. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.matpr.2018.08.062 |
It is part of: | Materials Today: Proceedings, 2018, vol. 5, p. 172-179 |
URI: | http://hdl.handle.net/2445/159988 |
Related resource: | https://doi.org/10.1016/j.matpr.2018.08.062 |
ISSN: | 2214-7853 |
Appears in Collections: | Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
698437.pdf | 749.46 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License