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Title: Facile synthesis of azocino[4,3-b]indoles by ring-closing metathesis
Author: Bennasar Fèlix, M. Lluïsa
Zulaica Gallego, Ester
Solé Arjó, Daniel
Alonso Serrano, Sandra
Keywords: Alcaloides
Metàtesi (Química)
Síntesi orgànica
Metathesis (Chemistry)
Organic synthesis
Issue Date: Jan-2007
Publisher: Elsevier B.V.
Abstract: The azocino[4,3-b]indole system, tricyclic substructure of the indole alkaloids apparicine and ervaticine, is efficiently assembled by ring-closing metathesis of 2-allyl-3-(allylaminomethyl)indoles. The metathesis sites are introduced into the indole nucleus by reductive amination of a 3-formyl derivative with allylamine, followed by a-lithiation with subsequent electrophilic trapping with acrolein.
Note: Versió postprint del document publicat a:
It is part of: Tetrahedron, 2007, vol. 63, num. 4, p. 861-866
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ISSN: 0040-4020
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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