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http://hdl.handle.net/2445/160425| Title: | Facile synthesis of azocino[4,3-b]indoles by ring-closing metathesis |
| Author: | Bennasar Fèlix, M. Lluïsa Zulaica Gallego, Ester Solé Arjó, Daniel Alonso Serrano, Sandra |
| Keywords: | Alcaloides Metàtesi (Química) Síntesi orgànica Alkaloids Metathesis (Chemistry) Organic synthesis |
| Issue Date: | Jan-2007 |
| Publisher: | Elsevier B.V. |
| Abstract: | The azocino[4,3-b]indole system, tricyclic substructure of the indole alkaloids apparicine and ervaticine, is efficiently assembled by ring-closing metathesis of 2-allyl-3-(allylaminomethyl)indoles. The metathesis sites are introduced into the indole nucleus by reductive amination of a 3-formyl derivative with allylamine, followed by a-lithiation with subsequent electrophilic trapping with acrolein. |
| Note: | Versió postprint del document publicat a: https://doi.org/10.1016/j.tet.2006.11.043 |
| It is part of: | Tetrahedron, 2007, vol. 63, num. 4, p. 861-866 |
| URI: | http://hdl.handle.net/2445/160425 |
| Related resource: | https://doi.org/10.1016/j.tet.2006.11.043 |
| ISSN: | 0040-4020 |
| Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| 555923.pdf | 315.64 kB | Adobe PDF | View/Open |
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