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Title: Time‐dependent cytotoxic properties of terpyridine‐based copper complexes
Author: Grau, Jordi
Caubet Marín, Amparo
Roubeau, Olivier
Montpeyó, David
Lorenzo, Julia
Gámez Enamorado, Patrick
Keywords: Coure
Citotoxicitat per mediació cel·lular
Medicaments antineoplàstics
Cell-mediated cytotoxicity
Antineoplastic agents
Issue Date: 24-Mar-2020
Publisher: Wiley-VCH
Abstract: Five copper complexes supported by terpyridine ligand were prepared and characterized, viz. [Cu3Cl4(Naphtpy)2][CuCl2] (1), [Cu2Cl2(Naphtpy)2](ClO4)2 (2), [CuCl2(Naphtpy)]2(MeOH)3(H2O) (3), [CuCl2(Cltpy)] (4) and [Cu(Cltpy)2](ClO4)2 (5); (where Naphtpy stands for 4'-((naphthalen-2-yl)methoxy)-2,2′:6′,2′′-terpyridine and Cltpy for 4′-chloro-2,2′:6′,2′′-terpyridine). Their DNA-interaction abilities were investigated, and their cytotoxic behaviors were examined with three cells lines, namely with human ovarian carcinoma cells (A2780) and its derived cisplatin-resistant line (A2780cis), and human cervix adenocarcinoma cells (HeLa). All compounds show good cytotoxic properties (especially after 72 h incubation). Remarkably, two compounds, i.e. 4 and 5, are almost inactive after 24 h (particularly 4), but are highly active after 72 h, with IC50 values in the low micromolar to submicromolar range. Compounds 1 and 2 induce necrosis, whereas late apoptosis is observed with 3−5, 4 exhibiting a behaviour close to that of cisplatin
Note: Versió postprint del document publicat a:
It is part of: ChemBioChem, 2020, vol. 21
Related resource:
ISSN: 1439-4227
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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