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http://hdl.handle.net/2445/161057
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DC Field | Value | Language |
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dc.contributor.author | Grau, Jordi | - |
dc.contributor.author | Caubet Marín, Amparo | - |
dc.contributor.author | Roubeau, Olivier | - |
dc.contributor.author | Montpeyó, David | - |
dc.contributor.author | Lorenzo, Julia | - |
dc.contributor.author | Gámez Enamorado, Patrick | - |
dc.date.accessioned | 2020-05-18T16:02:51Z | - |
dc.date.available | 2021-03-24T06:10:21Z | - |
dc.date.issued | 2020-03-24 | - |
dc.identifier.issn | 1439-4227 | - |
dc.identifier.uri | http://hdl.handle.net/2445/161057 | - |
dc.description.abstract | Five copper complexes supported by terpyridine ligand were prepared and characterized, viz. [Cu3Cl4(Naphtpy)2][CuCl2] (1), [Cu2Cl2(Naphtpy)2](ClO4)2 (2), [CuCl2(Naphtpy)]2(MeOH)3(H2O) (3), [CuCl2(Cltpy)] (4) and [Cu(Cltpy)2](ClO4)2 (5); (where Naphtpy stands for 4'-((naphthalen-2-yl)methoxy)-2,2′:6′,2′′-terpyridine and Cltpy for 4′-chloro-2,2′:6′,2′′-terpyridine). Their DNA-interaction abilities were investigated, and their cytotoxic behaviors were examined with three cells lines, namely with human ovarian carcinoma cells (A2780) and its derived cisplatin-resistant line (A2780cis), and human cervix adenocarcinoma cells (HeLa). All compounds show good cytotoxic properties (especially after 72 h incubation). Remarkably, two compounds, i.e. 4 and 5, are almost inactive after 24 h (particularly 4), but are highly active after 72 h, with IC50 values in the low micromolar to submicromolar range. Compounds 1 and 2 induce necrosis, whereas late apoptosis is observed with 3−5, 4 exhibiting a behaviour close to that of cisplatin | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley-VCH | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1002/cbic.202000154 | - |
dc.relation.ispartof | ChemBioChem, 2020, vol. 21 | - |
dc.relation.uri | https://doi.org/10.1002/cbic.202000154 | - |
dc.rights | (c) Wiley-VCH, 2020 | - |
dc.source | Articles publicats en revistes (Química Inorgànica i Orgànica) | - |
dc.subject.classification | Coure | - |
dc.subject.classification | Citotoxicitat per mediació cel·lular | - |
dc.subject.classification | Medicaments antineoplàstics | - |
dc.subject.other | Copper | - |
dc.subject.other | Cell-mediated cytotoxicity | - |
dc.subject.other | Antineoplastic agents | - |
dc.title | Time‐dependent cytotoxic properties of terpyridine‐based copper complexes | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 700518 | - |
dc.date.updated | 2020-05-18T16:02:51Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
Files in This Item:
File | Description | Size | Format | |
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700518.pdf | 1.53 MB | Adobe PDF | View/Open |
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