Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/161204
Title: Cerebellar resting-state functional connectivity in Parkinson's disease and multiple system atrophy: Characterization of abnormalities and potential for differential diagnosis at the single-patient level
Author: Baggio, Hugo César
Abós, Alexandra
Segura i Fàbregas, Bàrbara
Campabadal, Anna
Uribe Codesal, Carme
Giraldo, Darly M.
Pérez Soriano, Alexandra
Muñoz, Esteban
Compta, Yaroslau
Junqué i Plaja, Carme, 1955-
Martí Domènech, Ma. Josep
Keywords: Aprenentatge automàtic
Malalties neurodegeneratives
Malaltia de Parkinson
Machine learning
Neurodegenerative Diseases
Parkinson's disease
Issue Date: 1-Jan-2019
Publisher: Elsevier
Abstract: Background: Recent studies using resting-state functional connectivity and machine-learning to distinguish patients with neurodegenerative diseases from other groups of subjects show promising results. This approach has not been tested to discriminate between Parkinson's disease (PD) and multiple system atrophy (MSA) patients. Objectives: Our first aim is to characterize possible abnormalities in resting-state functional connectivity between the cerebellum and a set of intrinsic-connectivity brain networks and between the cerebellum and different regions of the striatum in PD and MSA. The second objective of this study is to assess the potential of cerebellar connectivity measures to distinguish between PD and MSA patients at the single-patient level. Methods: Fifty-nine healthy controls, 62 PD patients, and 30 MSA patients underwent resting-state functional MRI with a 3T scanner. Independent component analysis and dual regression were used to define seven restingstate networks of interest. To assess striatal connectivity, a seed-to-voxel approach was used after dividing the striatum into six regions bilaterally. Measures of cerebellar-brain network and cerebellar-striatal connectivity were then used as features in a support vector machine to discriminate between PD and MSA patients. Results: MSA patients displayed reduced cerebellar connectivity with different brain networks and with the striatum compared with PD patients and with controls. The classification procedure achieved an overall accuracy of 77.17% with 83.33% of the MSA subjects and 74.19% of the PD patients correctly classified. Conclusion: Our findings suggest that measures of cerebellar functional connectivity have the potential to distinguish between PD and MSA patients.
Note: Reproducció del document publicat a: https://doi.org/10.1016/j.nicl.2019.101720
It is part of: Neuroimage-Clinical, 2019, vol. 22, p. 101720
URI: http://hdl.handle.net/2445/161204
Related resource: https://doi.org/10.1016/j.nicl.2019.101720
ISSN: 2213-1582
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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