Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/161240
Title: Disrupted structural connectivity of fronto-deep gray matter pathways in progressive supranuclear palsy
Author: Abós, Alexandra
Segura i Fàbregas, Bàrbara
Baggio, Hugo César
Campabadal, Anna
Uribe Codesal, Carme
Garrido, Alicia
Camara, Ana
Muñoz, Esteban
Valldeoriola Serra, Francesc
Martí Domènech, Ma. Josep
Junqué i Plaja, Carme, 1955-
Compta, Yaroslau
Keywords: Malalties neurodegeneratives
Xarxes neuronals (Neurobiologia)
Neurodegenerative Diseases
Neural networks (Neurobiology)
Issue Date: 15-Jun-2019
Publisher: Elsevier
Abstract: Background: Structural connectivity is a promising methodology to detect patterns of neural network dysfunction in neurodegenerative diseases. This approach has not been tested in progressive supranuclear palsy (PSP). Objectives: The aim of this study is reconstructing the structural connectome to characterize and detect the pathways of degeneration in PSP patients compared with healthy controls and their correlation with clinical features. The second objective is to assess the potential of structural connectivity measures to distinguish between PSP patients and healthy controls at the single-subject level. Methods: Twenty healthy controls and 19 PSP patients underwent diffusion-weighted MRI with a 3T scanner. Structural connectivity, represented by number of streamlines, was derived from probabilistic tractography. Global and local network metrics were calculated based on graph theory. Results: Reduced numbers of streamlines were predominantly found in connections between frontal areas and deep gray matter (DGM) structures in PSP compared with controls. Significant changes in structural connectivity correlated with clinical features in PSP patients. An abnormal small-world architecture was detected in the subnetwork comprising the frontal lobe and DGM structures in PSP patients. The classification procedure achieved an overall accuracy of 82.23% with 94.74% sensitivity and 70% specificity. Conclusion: Our findings suggest that modelling the brain as a structural connectome is a useful method to detect changes in the organization and topology of white matter tracts in PSP patients. Secondly, measures of structural connectivity have the potential to correctly discriminate between PSP patients and healthy controls.
Note: Reproducció del document publicat a: https://doi.org/10.1016/j.nicl.2019.101899
It is part of: Neuroimage-Clinical, 2019, vol. 23, p. 101899
URI: http://hdl.handle.net/2445/161240
Related resource: https://doi.org/10.1016/j.nicl.2019.101899
ISSN: 2213-1582
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

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