Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/161441
Title: Indirect effects of paediatric conjugate vaccines on invasive pneumococcal disease in older adults
Author: Ciruela, Pilar
Broner, Sonia
Izquierdo, Conchita
Pallarés Giner, Roman
Muñoz-Almagro, Carmen
Hernandez, Sergi
Grau, Immaculada
Dominguez, Angela
Jané, Mireia
Keywords: Infeccions per pneumococs
Vacunació
Mortalitat
Meningitis cerebrospinal epidèmica
Pneumococcal Infections
Vaccination
Mortality
Cerebrospinal meningitis
Issue Date: 1-Sep-2019
Publisher: Elsevier B.V.
Abstract: Objectives: The aim of this study was to assess the indirect effect of paediatric 13-valent pneumococcal conjugate vaccine (PCV13) vaccination on people ≥65 years of age with invasive pneumococcal disease (IPD) in Catalonia and to determine factors predictive of mortality. Methods: During 2014-2016, 1285 IPD cases were reported to the Public Health Agency of Catalonia. The indirect effect of paediatric PCV13 vaccination was calculated by comparing the incidence rate (IR) in 2016 (PCV13 year) with that in 2009 (pre-PCV13). Predictors of mortality were determined using multivariate logistic regression. Results: Comparing 2016 and 2009, IPD decreased by 19% (IR 40.1 and 32.5 per 100 000 person-years, respectively). PCV13 serotypes decreased by 57% (IR 23.7 and 10.1), while non-PCV13 serotypes increased by 36% (IR 16.4 and 22.4). During 2014-2016, the mortality rate was 17.5%, and mortality was associated with age ≥85 years (adjusted odds ratio (aOR) 2.91, 95% confidence interval (CI) 1.89, 4.48), meningitis (aOR 2.29, 95% CI 1.25, 4.19), non-focal bacteraemia (aOR 3.73, 95% CI 2.00, 6.94), and ≥1 high-risk condition (aOR 1.89, 95% CI 1.08, 3.32). PPV23non13 serotypes were associated with lower mortality than PCV13 serotypes (aOR 0.54, 95% CI 0.34, 0.86). Conclusions: The incidence of IPD in people ≥65 years of age decreased after the introduction of paediatric PCV13, and this was due to a reduction in PCV13 serotypes, although an increase in non-PCV13 serotypes was observed. Mortality was associated with age, meningitis, non-focal bacteraemia, ≥1 high-risk condition, and PCV13 serotypes.
Note: Reproducció del document publicat a: https://doi.org/10.1016/j.ijid.2019.06.030
It is part of: International Journal of Infectious Diseases, 2019, vol. 86, p. 122-130
URI: http://hdl.handle.net/2445/161441
Related resource: https://doi.org/10.1016/j.ijid.2019.06.030
http://dx.doi.org/10.1016/j.ijid.2019.12.027
ISSN: 1201-9712
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Medicina)

Files in This Item:
File Description SizeFormat 
692469.pdf1.1 MBAdobe PDFView/Open
692469_corr.pdfCorrigndum226.03 kBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons