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|Title:||Prevalence, clinical characteristics and outcome of severe primary HIV-1 infection: a prospective cohort study|
Marcos, Ma. Angeles
Plana Prades, Montserrat
Mosquera, Maria Mar
Gatell, José M.
Miró Meda, José M.
|Keywords:||Infeccions per VIH|
Pacients amb lesions cerebrals
Brain damage patients
|Abstract:||Background: Severe cases of primary HIV infection have been described in patients presenting with neurological involvement, AIDS defining events or other life-threatening events. These severe forms have not been fully studied. Objectives: To determine the prevalence and characteristics of severe PHI in a hospital-based cohort of primary HIV infection, and the response to the early initiation of antiretroviral therapy (ART) at 12 months. Methods: Every patient with PHI attending Hospital Clínic of Barcelona (1997-2015) was evaluated. Severe PHI was defined using clinical, analytical and immunological criteria. Chi-squared test was used for categorical variables and Student's t-test for quantitative variables. Results: 33% of 224 PHI patients (95% CI: 26.84%-39.16%) had a severe PHI. These patients had more symptoms, abnormal analytical parameters and hospital admissions. The severe PHI group had a significantly higher viral load although no differences were observed at 12 months in terms of viral suppression or CD4 count recovery. None died during PHI. Conclusions: Up to one third of patients in our cohort presented with a severe PHI, which was associated with higher hospitalization rates and higher plasma HIV RNA viral load. However, severe forms were not associated to a worse clinical, immunological or virological outcome at 12 months.|
|Note:||Reproducció del document publicat a: https://doi.org/10.1016/j.ijid.2019.08.001|
|It is part of:||International Journal of Infectious Diseases, 2019, vol. 88, p. 73-79|
|Appears in Collections:||Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)|
Articles publicats en revistes (Fonaments Clínics)
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