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Title: Prevalence, clinical characteristics and outcome of severe primary HIV-1 infection: a prospective cohort study
Author: Nicolás, David
Suárez, Antonio
Ambrosioni, Juan
Manzardo, Christian
Ligero, Carmen
Costa, Josep
Fernández, Emma
Marcos, Ma. Angeles
Plana Prades, Montserrat
Mosquera, Maria Mar
Sánchez-Palomino, Sonsoles
Gatell, José M.
Miró Meda, José M.
Keywords: Infeccions per VIH
Pacients amb lesions cerebrals
HIV infections
Brain damage patients
Antiretroviral agents
Issue Date: 3-Aug-2019
Publisher: Elsevier B.V.
Abstract: Background: Severe cases of primary HIV infection have been described in patients presenting with neurological involvement, AIDS defining events or other life-threatening events. These severe forms have not been fully studied. Objectives: To determine the prevalence and characteristics of severe PHI in a hospital-based cohort of primary HIV infection, and the response to the early initiation of antiretroviral therapy (ART) at 12 months. Methods: Every patient with PHI attending Hospital Clínic of Barcelona (1997-2015) was evaluated. Severe PHI was defined using clinical, analytical and immunological criteria. Chi-squared test was used for categorical variables and Student's t-test for quantitative variables. Results: 33% of 224 PHI patients (95% CI: 26.84%-39.16%) had a severe PHI. These patients had more symptoms, abnormal analytical parameters and hospital admissions. The severe PHI group had a significantly higher viral load although no differences were observed at 12 months in terms of viral suppression or CD4 count recovery. None died during PHI. Conclusions: Up to one third of patients in our cohort presented with a severe PHI, which was associated with higher hospitalization rates and higher plasma HIV RNA viral load. However, severe forms were not associated to a worse clinical, immunological or virological outcome at 12 months.
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It is part of: International Journal of Infectious Diseases, 2019, vol. 88, p. 73-79
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ISSN: 1201-9712
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Fonaments Clínics)

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