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http://hdl.handle.net/2445/161478
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DC Field | Value | Language |
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dc.contributor.author | Nicolás, David | - |
dc.contributor.author | Suárez, Antonio | - |
dc.contributor.author | Ambrosioni, Juan | - |
dc.contributor.author | Manzardo, Christian | - |
dc.contributor.author | Ligero, Carmen | - |
dc.contributor.author | Costa, Josep | - |
dc.contributor.author | Fernández, Emma | - |
dc.contributor.author | Marcos, Ma. Angeles | - |
dc.contributor.author | Plana Prades, Montserrat | - |
dc.contributor.author | Mosquera, Maria Mar | - |
dc.contributor.author | Sánchez-Palomino, Sonsoles | - |
dc.contributor.author | Gatell, José M. | - |
dc.contributor.author | Miró Meda, José M. | - |
dc.date.accessioned | 2020-05-19T21:16:50Z | - |
dc.date.available | 2020-05-19T21:16:50Z | - |
dc.date.issued | 2019-08-03 | - |
dc.identifier.issn | 1201-9712 | - |
dc.identifier.uri | http://hdl.handle.net/2445/161478 | - |
dc.description.abstract | Background: Severe cases of primary HIV infection have been described in patients presenting with neurological involvement, AIDS defining events or other life-threatening events. These severe forms have not been fully studied. Objectives: To determine the prevalence and characteristics of severe PHI in a hospital-based cohort of primary HIV infection, and the response to the early initiation of antiretroviral therapy (ART) at 12 months. Methods: Every patient with PHI attending Hospital Clínic of Barcelona (1997-2015) was evaluated. Severe PHI was defined using clinical, analytical and immunological criteria. Chi-squared test was used for categorical variables and Student's t-test for quantitative variables. Results: 33% of 224 PHI patients (95% CI: 26.84%-39.16%) had a severe PHI. These patients had more symptoms, abnormal analytical parameters and hospital admissions. The severe PHI group had a significantly higher viral load although no differences were observed at 12 months in terms of viral suppression or CD4 count recovery. None died during PHI. Conclusions: Up to one third of patients in our cohort presented with a severe PHI, which was associated with higher hospitalization rates and higher plasma HIV RNA viral load. However, severe forms were not associated to a worse clinical, immunological or virological outcome at 12 months. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.ijid.2019.08.001 | - |
dc.relation.ispartof | International Journal of Infectious Diseases, 2019, vol. 88, p. 73-79 | - |
dc.relation.uri | https://doi.org/10.1016/j.ijid.2019.08.001 | - |
dc.rights | cc-by-nc-nd (c) Nicolás, David et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Fonaments Clínics) | - |
dc.subject.classification | Infeccions per VIH | - |
dc.subject.classification | Pacients amb lesions cerebrals | - |
dc.subject.classification | Antiretrovirals | - |
dc.subject.other | HIV infections | - |
dc.subject.other | Brain damage patients | - |
dc.subject.other | Antiretroviral agents | - |
dc.title | Prevalence, clinical characteristics and outcome of severe primary HIV-1 infection: a prospective cohort study | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 691892 | - |
dc.date.updated | 2020-05-19T21:16:50Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Fonaments Clínics) |
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691892.pdf | 762.12 kB | Adobe PDF | View/Open |
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