Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/161499
Title: A study of the properties, reactivity and anticancer activity of novel N- methylated-3-thiazolyl or 3-thienyl carbazoles and their Pd(II) and Pt(II) complexes
Author: Reig Canyelles, Marta
Bosque, Ramon
Font Bardia, Ma. Mercedes
Calvis, Carme
Messeguer i Peypoch, Ramon
Baldomà Llavinés, Laura
Badía Palacín, Josefa
Velasco Castrillo, Dolores
Lopez, Concepcion
Keywords: Bioquímica
Càncer
Biochemistry
Cancer
Issue Date: 1-Jul-2018
Publisher: Elsevier B.V.
Abstract: The synthesis and characterization of two hybrid N-methylated carbazole derivatives containing a thiazolyl or a thienyl ring is reported. The thiazolyl derivative has been also characterised by X-ray diffraction analysis. The study of its reactivity in front of [MCl2(dmso)(2)] (M = Pd or Pt) or Na-2[PdCl4] in methanol has allowed us to isolate and characterize its complexes. However, for the thienyl analogue, the formation of any Pd(II) or Pt(II) complex was not detected, indicating that it is less prone to bind to the M(II) ions than its thiazolyl analogue. Density Functional Theory (DFT) and Time-Dependent Density Functional Theory (TD-DFT) calculations have also been carried out in order to rationalize the influence of the nature of the thiazolyl or thienyl group on the electronic delocalization. Molecular mechanics calculations show that the free rotation of the thiazolyl in relation to the carbazole requires a greater energy income than for its thienyl analogue. Studies of the cytotoxic activity of the new compounds on colon (HCT116) and breast (MDA-MB231 and MCF7) cancer cell lines show that the thiazolyl carbazole ligand and its Pt(II) complex are the most active agents of the series and in the MCF7 line their potency is higher than that of cisplatin. In the non-tumoral human skin fibroblast BJ cell line, all the compounds were less toxic than cisplatin. Their potential ability to modify the electrophoretic mobility of pBluescript SK+ plasmid DNA and to act as inhibitors of Topoisomerases I and II alpha or cathepsin B has also been investigated.
Note: Versió postprint del document publicat a: https://doi.org/10.1016/j.jinorgbio.2018.03.008
It is part of: Journal of Inorganic Biochemistry, 2018, vol. 184, p. 134-145
URI: http://hdl.handle.net/2445/161499
Related resource: https://doi.org/10.1016/j.jinorgbio.2018.03.008
ISSN: 0162-0134
Appears in Collections:Articles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada)

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