Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/161798
Title: Ex Vivo Permeation of Carprofen Vehiculated by PLGA Nanoparticles through Porcine Mucous Membranes and Ophthalmic Tissues
Author: Gomez, Lidia
Parra Coca, Alexander
Calpena Campmany, Ana Cristina
Gimeno Sandig, Álvaro
Gómez de Aranda Pulgarín, Inmaculada
Boix Montañés, Antonio de Pádua
Keywords: Nanopartícules
Solucions (Farmàcia)
Sistemes d'alliberament de medicaments
Agents antiinflamatoris
Malalties dels animals
Porc
Assaigs clínics
Nanoparticles
Solutions (Pharmacy)
Drug delivery systems
Antiinflammatory agents
Animal diseases
Swine
Clinical trials
Issue Date: 18-Feb-2020
Publisher: MDPI
Abstract: (1) Background: Carprofen (CP), 2-(6-chlorocarbazole) propionic acid, is used as an anti-inflammatory, analgesic and anti-pyretic agent and it belongs to the family of non-steroidal anti-inflammatory drugs (NSAIDs). CP has some adverse reactions in systemic administration; for this reason, topical administration with CP nanoparticles (CP-NPs) can be an optimal alternative. The main objective of this work is the investigation of ex vivo permeation of CP through different types of porcine mucous membranes (buccal, sublingual and vaginal) and ophthalmic tissues (cornea, sclera and conjunctiva) to compare the influence of CP-NPs formulation over a CP solution (CP-Solution). (2) Methods: The ex vivo permeation profiles were evaluated using Franz diffusion cells. Furthermore, in vivo studies were performed to verify that the formulations did not affect the cell structure and to establish the amount retained (Qr) in the tissues. (3) Results: Permeation of CP-NPs is more effective in terms of drug retention in almost all tissues (with the exception of sclera and sublingual). In vivo studies show that neither of the two formulations affects tissue structure, so both formulations are safe. (4) Conclusions: It was concluded that CP-NPs may be a useful tool for the topical treatment of local inflammation in veterinary and human medicine.
Note: Reproducció del document publicat a: https://doi.org/10.3390/nano10020355
It is part of: Nanomaterials, 2020, vol. 10, num. 2, p. 355
URI: http://hdl.handle.net/2445/161798
Related resource: https://doi.org/10.3390/nano10020355
ISSN: 2079-4991
Appears in Collections:Articles publicats en revistes (Institut de Nanociència i Nanotecnologia (IN2UB))
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

Files in This Item:
File Description SizeFormat 
699241.pdf5.99 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons