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http://hdl.handle.net/2445/161866
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DC Field | Value | Language |
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dc.contributor.author | Máiz, Luis | - |
dc.contributor.author | Girón, Rosa María | - |
dc.contributor.author | Prats, E. | - |
dc.contributor.author | Clemente, Marta G. | - |
dc.contributor.author | Polverino, Eva | - |
dc.contributor.author | Caño, Silvia | - |
dc.contributor.author | Cordovilla, Rosa | - |
dc.contributor.author | Dorca i Sargatal, Jordi | - |
dc.contributor.author | Peñalver, Carlos | - |
dc.contributor.author | Baranda, Félix | - |
dc.contributor.author | Martínez García, Miguel Ángel | - |
dc.date.accessioned | 2020-05-21T08:40:36Z | - |
dc.date.available | 2020-05-21T08:40:36Z | - |
dc.date.issued | 2018-01 | - |
dc.identifier.issn | 1753-4658 | - |
dc.identifier.uri | http://hdl.handle.net/2445/161866 | - |
dc.description.abstract | Background: The excessive retention of sputum in the airways, leading to pulmonary infections, is a common consequence of bronchiectasis. Although inhalation of 7% hypertonic saline (HS) has proven an effective method to help remove the mucus, many patients are intolerant of this treatment. The addition of 0.1% hyaluronic acid to HS (HS+HA) could increase tolerance to HS in these patients. The main objective of this study was to evaluate the tolerability of HS+HA in bronchiectasis patients who are intolerant to HS. Methods: This prospective, observational, open-label study analysed the outcomes of two groups of bronchiectasis patients previously scheduled to start HS therapy. Patients were assessed for tolerance to HS by a questionnaire, spirometry and clinical evaluation. Patients who were intolerant were evaluated for tolerance to HS+HA approximately one week later. All patients were evaluated for their tolerance to HS or HS+HA 4 weeks after the start of their treatment. Patients were also assessed with quality-of-life and adherence questionnaires, and all adverse events were registered. Results: A total of 137 bronchiectasis patients were enrolled in the study (age = 63.0 ± 14.7 years; 63.5% women). Of these, 92 patients (67.1%) were tolerant and 45 patients (32.9%) were intolerant to HS. Of the 45 patients intolerant to HS, 31 patients (68.9%) were tolerant and 14 patients (31.1%) intolerant to HS+HA. Of these 31 tolerant patients, 26 (83.9%) could complete the 4-week treatment with HS+HA. Conclusions: Two-thirds of bronchiectasis patients that presented intolerance to inhaled HS alone are tolerant to inhaled HS+HA, suggesting that HA improves tolerance to HS therapy. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | SAGE Publications | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1177/1753466618787385 | - |
dc.relation.ispartof | Therapeutic Advances In Respiratory Disease, 2018, vol. 12, p. 1-10 | - |
dc.relation.uri | https://doi.org/10.1177/1753466618787385 | - |
dc.rights | cc-by-nc (c) Máiz, Luis et al., 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Infeccions respiratòries | - |
dc.subject.classification | Malalties pulmonars obstructives cròniques | - |
dc.subject.other | Respiratory infections | - |
dc.subject.other | Chronic obstructive pulmonary diseases | - |
dc.title | Addition of hyaluronic acid improves tlerance to 7% hypertonic saline solution in bronchiectasis patients. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 684666 | - |
dc.date.updated | 2020-05-21T08:40:36Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 30014774 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Ciències Clíniques) |
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684666.pdf | 353.95 kB | Adobe PDF | View/Open |
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