Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/161920
Title: α-parvin is required for epidermal morphogenesis, hair follicle development and basal keratinocyte polarity
Author: Altstätter, Johannes
Hess, Michael W.
Costell, Mercedes
Montañez, Eloi
Keywords: Epidermis
Morfogènesi
Cèl·lules
Epidermis
Morphogenesis
Cells
Issue Date: 12-Mar-2020
Publisher: Public Library of Science (PLoS)
Abstract: Epidermal morphogenesis and hair follicle (HF) development depend on the ability of keratinocytes to adhere to the basement membrane (BM) and migrate along the extracellular matrix. Integrins are cell-matrix receptors that control keratinocyte adhesion and migration, and are recognized as major regulators of epidermal homeostasis. How integrins regulate the behavior of keratinocytes during epidermal morphogenesis remains insufficiently understood. Here, we show that α-parvin (α-pv), a focal adhesion protein that couples integrins to actin cytoskeleton, is indispensable for epidermal morphogenesis and HF development. Inactivation of the murine α-pv gene in basal keratinocytes results in keratinocyte-BM detachment, epidermal thickening, ectopic keratinocyte proliferation and altered actin cytoskeleton polarization. In vitro, α-pv-null keratinocytes display reduced adhesion to BM matrix components, aberrant spreading and stress fibers formation, and impaired directed migration. Together, our data demonstrate that α-pv controls epidermal homeostasis by facilitating integrin-mediated adhesion and actin cytoskeleton organization in keratinocytes.
Note: Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0230380
It is part of: PLoS One, 2020, vol. 15, num. 3, p. e0230380
URI: http://hdl.handle.net/2445/161920
Related resource: https://doi.org/10.1371/journal.pone.0230380
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Fisiològiques)

Files in This Item:
File Description SizeFormat 
699927.pdf4.42 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons