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Title: Age at first episode modulates diagnosis-related structurals brain abnormalities in patients with first-episode psychosis.
Author: Pina Camacho, Laura
Del Rey Mejias, Angel
Janssen, Joost
Bioque Alcázar, Miquel
González-Pinto, Ana
Arango, Celso
Lobo, Antonio
Sarró, Salvador
Desco, Manuel
Sanjuan, Julio
Lacalle-Aurioles, M.
Cuesta, Manuel J.
Sáiz Ruiz, Jerónimo
Bernardo Arroyo, Miquel
Parellada, Mara
PEPs Group
Keywords: Psicosi
Human abnormalities
Issue Date: 2016
Publisher: Oxford University Press
Abstract: Brain volume and thickness abnormalities have been reported in first-episode psychosis (FEP). However, it is unclear if and how they are modulated by brain developmental stage (and, therefore, by age at FEP as a proxy). This is a multicenter cross-sectional case-control brain magnetic resonance imaging (MRI) study. Patients with FEP (n = 196), 65.3% males, with a wide age at FEP span (12-35 y), and healthy controls (HC) (n = 157), matched for age, sex, and handedness, were scanned at 6 sites. Gray matter volume and thickness measurements were generated for several brain regions using FreeSurfer software. The nonlinear relationship between age at scan (a proxy for age at FEP in patients) and volume and thickness measurements was explored in patients with schizophrenia spectrum disorders (SSD), affective psychoses (AFP), and HC. Earlier SSD cases (ie, FEP before 15-20 y) showed significant volume and thickness deficits in frontal lobe, volume deficits in temporal lobe, and volume enlargements in ventricular system and basal ganglia. First-episode AFP patients had smaller cingulate cortex volume and thicker temporal cortex only at early age at FEP (before 18-20 y). The AFP group also had age-constant (12-35-y age span) volume enlargements in the frontal and parietal lobe. Our study suggests that age at first episode modulates the structural brain abnormalities found in FEP patients in a nonlinear and diagnosis-dependent manner. Future MRI studies should take these results into account when interpreting samples with different ages at onset and diagnosis.
Note: reproducció del document publicat a:
It is part of: Schizophrenia Bulletin, 2016, vol. 42, num. 2, p. 344-357
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ISSN: 0586-7614
Appears in Collections:Articles publicats en revistes (Medicina)

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