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http://hdl.handle.net/2445/162031
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DC Field | Value | Language |
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dc.contributor.author | Molinar Toribio, Eunice María | - |
dc.contributor.author | Ramos Romero, Sara | - |
dc.contributor.author | Fuguet i Jordà, Elisabet | - |
dc.contributor.author | Taltavull, Núria | - |
dc.contributor.author | Méndez, Lucía | - |
dc.contributor.author | Romeu Ferran, Marta | - |
dc.contributor.author | Medina, Isabel | - |
dc.contributor.author | Torres, Josep Lluís | - |
dc.contributor.author | Pérez-Jiménez, Jara | - |
dc.date.accessioned | 2020-05-22T10:52:34Z | - |
dc.date.available | 2020-05-22T10:52:34Z | - |
dc.date.issued | 2017-03-25 | - |
dc.identifier.issn | 0963-9969 | - |
dc.identifier.uri | http://hdl.handle.net/2445/162031 | - |
dc.description.abstract | Studies of the bioavailability of proanthocyanidins usually consider them independently of other dietary constituents, while there is a tendency in the field of functional foods towards the combination of different bioactive compounds in a single product. This study examined the long-term effects of ω-3 polyunsaturated fatty acids of marine origin on the metabolic fate of grape proanthocyanidins. For this, female adult Wistar-Kyoto rats were fed (18 weeks) with a standard diet supplemented or not with eicosapentaenoic acid/docosahexaenoic acid (1:1, 16.6 g/kg feed), proanthocyanidin-rich grape seed extract (0.8 g/kg feed) or both. A total of 39 microbial-derived metabolites and 16 conjugated metabolites were detected by HPLC-MS/MS either in urine or in the aqueous fraction of feces. An unexpected significant increase in many proanthocyanidin metabolites in urine and feces was observed in the group supplemented with ω-3 polyunsaturated fatty acids group as compared to the animals fed a standard diet, which contains a small amount of polyphenols. However, proanthocyanidin metabolites in rats given ω-3 polyunsaturated fatty acids and grape seed extract did not significantly differ from those in the group supplemented only with grape seed extract. It was concluded that ω-3 polyunsaturated fatty acids collaborate in the metabolism of polyphenols when present at low doses in the feed matrix, while the capacity of ω-3 polyunsaturated fatty acids to induce microbiota transformations when proanthocyanidins are present at high doses is not relevant compared to that of polyphenols themselves. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.foodres.2017.03.046 | - |
dc.relation.ispartof | Food Research International, 2017, vol. 97, p. 133-140 | - |
dc.relation.uri | https://doi.org/10.1016/j.foodres.2017.03.046 | - |
dc.rights | cc-by-nc-nd (c) Elsevier B.V., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Enginyeria Química i Química Analítica) | - |
dc.subject.classification | Polifenols | - |
dc.subject.classification | Biodisponibilitat | - |
dc.subject.classification | Àcids grassos omega-3 | - |
dc.subject.other | Polyphenols | - |
dc.subject.other | Bioavailability | - |
dc.subject.other | Omega-3 fatty acids | - |
dc.title | Influence of omega-3 PUFAs on the metabolism of proanthocyanidins in rats | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 672733 | - |
dc.date.updated | 2020-05-22T10:52:35Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Enginyeria Química i Química Analítica) |
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File | Description | Size | Format | |
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672733.pdf | 675.79 kB | Adobe PDF | View/Open |
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