Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/162039
Title: Nigral and striatal connectivity alterations in asymptomatic LRRK2 mutation carriers: A magnetic resonance imaging study
Author: Vilas Rolán, Dolores
Segura i Fàbregas, Bàrbara
Baggio, Hugo César
Pont Sunyer, Claustre
Compta, Yaroslau
Valldeoriola Serra, Francesc
Martí Domènech, Ma. Josep
Quintana, Maria
Bayés, Àngels
Hernández Vara, Jorge
Calopa, Matilde
Aguilar, Miquel
Junqué i Plaja, Carme, 1955-
Tolosa, Eduardo
Barcelona LRRK2 Study Group
Keywords: Imatges per ressonància magnètica
Malaltia de Parkinson
Escorça cerebral
Magnetic resonance imaging
Parkinson's disease
Cerebral cortex
Issue Date: 21-Sep-2016
Publisher: Wiley
Abstract: Background. The study of the functional connectivity by means of magnetic resonance imaging (MRI) in asymptomatic LRRK2 mutation carriers could contribute to the characterization of the prediagnostic phase of LRRK2 associated Parkinson's disease (PD). Objective. To characterize MRI functional patterns during resting state in asymptomatic LRRK2 mutation carriers. Methods. We acquired structural and functional MRI data of 18 asymptomatic LRRK2 mutation carriers and 18 asymptomatic LRRK2 mutation noncarriers, all first-degree relatives of LRRK2-PD patients. Starting from resting state data, we analyzed the functional connectivity of the striatocortical and the nigrocortical circuitry. Structural brain data was analyzed by voxel based morphometry, cortical thickness and volumetric measures. Results: Asymptomatic LRRK2 mutation carriers had functional connectivity reductions between the caudal motor part of the left striatum and ipsilateral precuneus and superior parietal lobe. Connectivity in these regions correlated with subcortical gray matter volumes in mutation carriers. Asymptomatic carriers also showed increased connectivity between the right substantia nigra and bilateral occipital cortical regions (occipital pole and cuneus bilaterally, and right lateral occipital cortex). No intergroup differences in structural MRI measures were found. In LRRK2 mutation carriers, age and functional connectivity correlated negatively with striatal volumes. Additional analyses including only subjects with the G2019S mutation revealed similar findings. Conclusion: Asymptomatic LRRK2 mutation carriers showed functional connectivity changes in striatocortical and nigrocortical circuits compared with noncarriers. These findings support the concept that altered brain connectivity precedes the onset of classical motor features in a genetic form of PD.
Note: Versió postprint del document publicat a: https://doi.org/10.1002/mds.26799
It is part of: Movement Disorders, 2016, vol. 31, num. 12, p. 1820-1828
URI: http://hdl.handle.net/2445/162039
Related resource: https://doi.org/10.1002/mds.26799
ISSN: 0885-3185
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

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