Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/162279
Title: Fate of d‑fagomine after oral administration to rats
Author: Amézqueta, Susana
Ramos Romero, Sara
Martínez-Guimet, C.
Moreno, Albert
Hereu, Mercè
Torres, Josep Lluís
Keywords: Glucòsids
Infeccions per escheríchia coli
Infeccions del tracte urinari
Glucosides
Escherichia coli infections
Urinary tract infections
Issue Date: 10-May-2017
Publisher: American Chemical Society
Abstract: D-Fagomine is an iminosugar found in buckwheat that is capable of inhibiting the adhesion of potentially pathogenic bacteria to epithelial mucosa and of reducing postprandial blood glucose concentration. This paper evaluates the excretion and metabolism of orally administered D-fagomine in rats and compares outcomes with the fate of 1-deoxynojirimycin. D-Fagomine and 1- deoxynojirimycin show similar absorption and excretion kinetics. D-Fagomine is partly absorbed (41-84%, dose 2 mg/kg body weight) and excreted in urine within 8 h while non-absorbed fraction is cleared in feces within 24 h. D-Fagomine is partially methylated (about 10% in urine and 3% in feces). The concentration of D-fagomine in urine from 1 to 6 h after administration is higher than 10 mg/L, the concentration that inhibits adhesion of Escherichia coli. Orally administered D-fagomine is partially absorbed and then rapidly excreted in urine were it reaches a concentration that may be protective against urinary tract infections.
Note: Versió postprint del document publicat a: https://doi.org/10.1021/acs.jafc.7b01026
It is part of: Journal of Agricultural and Food Chemistry, 2017, vol. 65, num. 22, p. 4414-4420
URI: http://hdl.handle.net/2445/162279
Related resource: https://doi.org/10.1021/acs.jafc.7b01026
ISSN: 0021-8561
Appears in Collections:Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
Articles publicats en revistes (Enginyeria Química i Química Analítica)

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