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Title: Eubiotic effect of buckwheat D-fagomine in healthy rats
Author: Hereu, Mercè
Ramos Romero, Sara
García-González, Natalia
Amézqueta, Susana
Torres, Josep Lluís
Keywords: Lactobacils
Issue Date: 16-Sep-2018
Publisher: Elsevier
Abstract: Diversity and balance of gut microorganisms is fundamental for health throughout life. The aim of this study is to explore the possible eubiotic effect of the buckwheat iminosugar D-fagomine (0.096% w/w in standard feed) in growing healthy Wistar Kyoto rats. Feed and energy intake, residual energy in feces, and body weight gain were independent of D-fagomine supplementation throughout the intervention (24 weeks). The populations of significant bacterial subgroups and species were determined in fecal and cecal DNA by quantitative real-time PCR. D-Fagomine increased the Bacteroidetes:Firmicutes ratio and partially counteracted the loss of Lactobacilliales and Bifidobacteriales over time. The supplementation reduced the levels of excreted short- chain fatty acids (SCFAs) as determined by gas chromatography. This paper provides preliminary evidence that D-fagomine has the capacity to promote microbial functional diversity by increasing the Bacteroidetes:Firmicutes ratio and to mitigate the age-related reduction in populations of the putatively beneficial Lactobacilliales and Bifidobacteriales.
Note: Versió postprint del document publicat a:
It is part of: Journal of Functional Foods, 2018, vol. 50, p. 120-126
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ISSN: 1756-4646
Appears in Collections:Articles publicats en revistes (Enginyeria Química i Química Analítica)

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