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Title: Functional effects of the buckwheat iminosugar D-fagomine on rats with diet-induced prediabetes
Author: Ramos Romero, Sara
Hereu, Mercè
Atienza, Lidia
Casas, Josefina
Taltavull, Núria
Romeu Ferran, Marta
Amézqueta, Susana
Dasilva, Gabriel
Medina, Isabel
Torres, Josep Lluís
Keywords: Microbiota
Issue Date: 2018
Publisher: Wiley-VCH
Abstract: Scope: The goals of this work were to test if D-fagomine, an iminosugar that reduces body weight gain, can delay the appearance of a fat-induced prediabetic state in a rat model and to explore possible mechanisms behind its functional action. Methods and results: Wistar Kyoto rats were fed a high-fat diet supplemented with D7 fagomine (or not; for comparison) or a standard diet (controls) for 24 weeks. The variables measured were: fasting blood glucose and insulin levels; glucose tolerance; diacylglycerols as intracellular mediators of insulin resistance in adipose tissue, liver and muscle; inflammation markers (plasma IL-6 and leptin, and liver and adipose tissue histology markers); eicosanoids from arachidonic acid as lipid mediators of inflammation; and the populations of Bacteroidetes, Firmicutes, Enterobacteriales and Bifidobacteriales in feces. We found that D-fagomine reduces fat-induced impaired glucose tolerance, inflammation markers and mediators (hepatic microgranulomas and lobular inflammation, plasma IL-6, prostaglandin E2 and leukotriene B4) while attenuating the changes in the populations of Enterobacteriales and Bifidobacteriales. Conclusion: D-Fagomine delays the development of a fat-induced prediabetic state in rats by reducing low-grade inflammation. We suggest that the anti-inflammatory effect of D-fagomine may be linked to a reduction in fat-induced overpopulation of minor gut bacteria.
Note: Versió postprint del document publicat a:
It is part of: Molecular Nutrition & Food Research, 2018, vol. 62, num. 16, p. 1800373
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ISSN: 1613-4125
Appears in Collections:Articles publicats en revistes (Enginyeria Química i Química Analítica)

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