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http://hdl.handle.net/2445/162312
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DC Field | Value | Language |
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dc.contributor.author | Ramos Romero, Sara | - |
dc.contributor.author | Hereu, Mercè | - |
dc.contributor.author | Atienza, Lidia | - |
dc.contributor.author | Casas, Josefina | - |
dc.contributor.author | Taltavull, Núria | - |
dc.contributor.author | Romeu Ferran, Marta | - |
dc.contributor.author | Amézqueta, Susana | - |
dc.contributor.author | Dasilva, Gabriel | - |
dc.contributor.author | Medina, Isabel | - |
dc.contributor.author | Torres, Josep Lluís | - |
dc.date.accessioned | 2020-05-25T14:31:59Z | - |
dc.date.available | 2020-05-25T14:31:59Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1613-4125 | - |
dc.identifier.uri | http://hdl.handle.net/2445/162312 | - |
dc.description.abstract | Scope: The goals of this work were to test if D-fagomine, an iminosugar that reduces body weight gain, can delay the appearance of a fat-induced prediabetic state in a rat model and to explore possible mechanisms behind its functional action. Methods and results: Wistar Kyoto rats were fed a high-fat diet supplemented with D7 fagomine (or not; for comparison) or a standard diet (controls) for 24 weeks. The variables measured were: fasting blood glucose and insulin levels; glucose tolerance; diacylglycerols as intracellular mediators of insulin resistance in adipose tissue, liver and muscle; inflammation markers (plasma IL-6 and leptin, and liver and adipose tissue histology markers); eicosanoids from arachidonic acid as lipid mediators of inflammation; and the populations of Bacteroidetes, Firmicutes, Enterobacteriales and Bifidobacteriales in feces. We found that D-fagomine reduces fat-induced impaired glucose tolerance, inflammation markers and mediators (hepatic microgranulomas and lobular inflammation, plasma IL-6, prostaglandin E2 and leukotriene B4) while attenuating the changes in the populations of Enterobacteriales and Bifidobacteriales. Conclusion: D-Fagomine delays the development of a fat-induced prediabetic state in rats by reducing low-grade inflammation. We suggest that the anti-inflammatory effect of D-fagomine may be linked to a reduction in fat-induced overpopulation of minor gut bacteria. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley-VCH | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1002/mnfr.201800373 | - |
dc.relation.ispartof | Molecular Nutrition & Food Research, 2018, vol. 62, num. 16, p. 1800373 | - |
dc.relation.uri | https://doi.org/10.1002/mnfr.201800373 | - |
dc.rights | (c) Wiley-VCH, 2018 | - |
dc.source | Articles publicats en revistes (Enginyeria Química i Química Analítica) | - |
dc.subject.classification | Microbiota | - |
dc.subject.classification | Diabetis | - |
dc.subject.classification | Obesitat | - |
dc.subject.other | Microbiota | - |
dc.subject.other | Diabetes | - |
dc.subject.other | Obesity | - |
dc.title | Functional effects of the buckwheat iminosugar D-fagomine on rats with diet-induced prediabetes | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 683721 | - |
dc.date.updated | 2020-05-25T14:32:00Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Enginyeria Química i Química Analítica) |
Files in This Item:
File | Description | Size | Format | |
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683721.pdf | 688.81 kB | Adobe PDF | View/Open |
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