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http://hdl.handle.net/2445/162326
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DC Field | Value | Language |
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dc.contributor.author | Ramos Romero, Sara | - |
dc.contributor.author | Hereu, Mercè | - |
dc.contributor.author | Atienza, Lidia | - |
dc.contributor.author | Amézqueta, Susana | - |
dc.contributor.author | Casas, Josefina | - |
dc.contributor.author | Muñoz, Silvia | - |
dc.contributor.author | Medina, Isabel | - |
dc.contributor.author | Miralles-Pérez, Bernat | - |
dc.contributor.author | Romeu Ferran, Marta | - |
dc.contributor.author | Torres, Josep Lluís | - |
dc.date.accessioned | 2020-05-25T15:32:01Z | - |
dc.date.available | 2020-10-28T06:10:25Z | - |
dc.date.issued | 2019-10-28 | - |
dc.identifier.issn | 1613-4125 | - |
dc.identifier.uri | http://hdl.handle.net/2445/162326 | - |
dc.description.abstract | Scope: This study examines the long-term functional effects of D-fagomine on sucrose4 induced factors of metabolic dysfunctions and explores possible molecular mechanisms behind its action. Methods & results: Wistar Kyoto (WKY) rats were fed a 35% sucrose solution with D- fagomine (or not, for comparison) or mineral water (controls) for 24 weeks. We recorded: body weight; energy intake; glucose tolerance; plasma leptin concentration and lipid profile; populations of Bacteroidetes, Firmicutes, bacteroidales, clostridiales, enterobacteriales, and Escherichia coli in feces; blood pressure; urine uric acid and F2t isoprostanes (F2-IsoPs); perigonadal fat deposition; and hepatic histology and diacylglycerols (DAGs) in liver and adipose tissue. D-Fagomine reduced sucrose-induced hypertension, urine uric acid and F2-IsoPs (markers of oxidative stress; OS), steatosis and liver DAGs, without significantly affecting perigonadal fat deposition and impaired glucose tolerance. It also promoted excretion of enterobacteriales generated by the dietary intervention. Conclusion: D-fagomine counteracts sucrose-induced steatosis and hypertension, presumably by reducing the postprandial levels of fructose in the liver. | - |
dc.format.extent | 32 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley-VCH | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1002/mnfr.201900564 | - |
dc.relation.ispartof | Molecular Nutrition & Food Research, 2019, vol. 64, num. 1, p. 1900564-1900564 | - |
dc.relation.uri | https://doi.org/10.1002/mnfr.201900564 | - |
dc.rights | (c) Wiley-VCH, 2019 | - |
dc.source | Articles publicats en revistes (Enginyeria Química i Química Analítica) | - |
dc.subject.classification | Metagenòmica | - |
dc.subject.classification | Obesitat | - |
dc.subject.classification | Diabetis | - |
dc.subject.classification | Pressió sanguínia | - |
dc.subject.other | Metagenomics | - |
dc.subject.other | Obesity | - |
dc.subject.other | Diabetes | - |
dc.subject.other | Blood pressure | - |
dc.title | The buckwheat iminosugar d-fagomine attenuates sucrose-induced steatosis and hypertension in rats | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 695831 | - |
dc.date.updated | 2020-05-25T15:32:01Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Enginyeria Química i Química Analítica) |
Files in This Item:
File | Description | Size | Format | |
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695831.pdf | 472.59 kB | Adobe PDF | View/Open |
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