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Title: | Metabolites related to purine catabolism and risk of type 2 diabetes incidence; modifying effects of the TCF7L2-rs7903146 polymorphism. |
Author: | Papandreou, Christopher Li, Jun Liang, Liming Bulló, Mònica Zheng, Yan Ruiz Canela, Miguel Yu, Edward Guasch-Ferré, Marta Razquin, Clary Clish, Clary B. Corella Piquer, Dolores Estruch Riba, Ramon Ros Rahola, Emilio Fitó Colomer, Montserrat Arós, Fernando Serra Majem, Lluís Rosique Esteban, Núria Martínez-González, Miguel Ángel, 1957- Hu, Frank B. Salas Salvadó, Jordi |
Keywords: | Metabòlits Diabetis no-insulinodependent Polimorfisme (Cristal·lografia) Metabolites Non-insulin-dependent diabetes Polymorphism (Crystallography) |
Issue Date: | 27-Feb-2019 |
Publisher: | Nature Publishing Group |
Abstract: | Studies examining associations between purine metabolites and type 2 diabetes (T2D) are limited. We prospectively examined associations between plasma levels of purine metabolites with T2D risk and the modifying effects of transcription factor-7-like-2 (TCF7L2) rs7903146 polymorphism on these associations. This is a case-cohort design study within the PREDIMED study, with 251 incident T2D cases and a random sample of 694 participants (641 non-cases and 53 overlapping cases) without T2D at baseline (median follow-up: 3.8 years). Metabolites were semi-quantitatively profiled with LC-MS/MS. Cox regression analysis revealed that high plasma allantoin levels, including allantoin-to-uric acid ratio and high xanthine-to-hypoxanthine ratio were inversely and positively associated with T2D risk, respectively, independently of classical risk factors. Elevated plasma xanthine and inosine levels were associated with a higher T2D risk in homozygous carriers of the TCF7L2-rs7903146 T-allele. The potential mechanisms linking the aforementioned purine metabolites and T2D risk must be also further investigated. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41598-019-39441-6 |
It is part of: | Scientific Reports, 2019, vol. 9, p. 2892 |
URI: | http://hdl.handle.net/2445/162521 |
Related resource: | https://doi.org/10.1038/s41598-019-39441-6 |
ISSN: | 2045-2322 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
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