Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/162521
Title: Metabolites related to purine catabolism and risk of type 2 diabetes incidence; modifying effects of the TCF7L2-rs7903146 polymorphism.
Author: Papandreou, Christopher
Li, Jun
Liang, Liming
Bulló, Mònica
Zheng, Yan
Ruiz Canela, Miguel
Yu, Edward
Guasch-Ferré, Marta
Razquin, Clary
Clish, Clary B.
Corella Piquer, Dolores
Estruch Riba, Ramon
Ros Rahola, Emilio
Fitó Colomer, Montserrat
Arós, Fernando
Serra Majem, Lluís
Rosique Esteban, Núria
Martínez-González, Miguel Ángel, 1957-
Hu, Frank B.
Salas Salvadó, Jordi
Keywords: Metabòlits
Diabetis no-insulinodependent
Polimorfisme (Cristal·lografia)
Metabolites
Non-insulin-dependent diabetes
Polymorphism (Crystallography)
Issue Date: 27-Feb-2019
Publisher: Nature Publishing Group
Abstract: Studies examining associations between purine metabolites and type 2 diabetes (T2D) are limited. We prospectively examined associations between plasma levels of purine metabolites with T2D risk and the modifying effects of transcription factor-7-like-2 (TCF7L2) rs7903146 polymorphism on these associations. This is a case-cohort design study within the PREDIMED study, with 251 incident T2D cases and a random sample of 694 participants (641 non-cases and 53 overlapping cases) without T2D at baseline (median follow-up: 3.8 years). Metabolites were semi-quantitatively profiled with LC-MS/MS. Cox regression analysis revealed that high plasma allantoin levels, including allantoin-to-uric acid ratio and high xanthine-to-hypoxanthine ratio were inversely and positively associated with T2D risk, respectively, independently of classical risk factors. Elevated plasma xanthine and inosine levels were associated with a higher T2D risk in homozygous carriers of the TCF7L2-rs7903146 T-allele. The potential mechanisms linking the aforementioned purine metabolites and T2D risk must be also further investigated.
Note: Reproducció del document publicat a: https://doi.org/10.1038/s41598-019-39441-6
It is part of: Scientific Reports, 2019, vol. 9, p. 2892
URI: http://hdl.handle.net/2445/162521
Related resource: https://doi.org/10.1038/s41598-019-39441-6
ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

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