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http://hdl.handle.net/2445/162521
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DC Field | Value | Language |
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dc.contributor.author | Papandreou, Christopher | - |
dc.contributor.author | Li, Jun | - |
dc.contributor.author | Liang, Liming | - |
dc.contributor.author | Bulló, Mònica | - |
dc.contributor.author | Zheng, Yan | - |
dc.contributor.author | Ruiz Canela, Miguel | - |
dc.contributor.author | Yu, Edward | - |
dc.contributor.author | Guasch-Ferré, Marta | - |
dc.contributor.author | Razquin, Clary | - |
dc.contributor.author | Clish, Clary B. | - |
dc.contributor.author | Corella Piquer, Dolores | - |
dc.contributor.author | Estruch Riba, Ramon | - |
dc.contributor.author | Ros Rahola, Emilio | - |
dc.contributor.author | Fitó Colomer, Montserrat | - |
dc.contributor.author | Arós, Fernando | - |
dc.contributor.author | Serra Majem, Lluís | - |
dc.contributor.author | Rosique Esteban, Núria | - |
dc.contributor.author | Martínez-González, Miguel Ángel, 1957- | - |
dc.contributor.author | Hu, Frank B. | - |
dc.contributor.author | Salas Salvadó, Jordi | - |
dc.date.accessioned | 2020-05-26T21:31:27Z | - |
dc.date.available | 2020-05-26T21:31:27Z | - |
dc.date.issued | 2019-02-27 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/162521 | - |
dc.description.abstract | Studies examining associations between purine metabolites and type 2 diabetes (T2D) are limited. We prospectively examined associations between plasma levels of purine metabolites with T2D risk and the modifying effects of transcription factor-7-like-2 (TCF7L2) rs7903146 polymorphism on these associations. This is a case-cohort design study within the PREDIMED study, with 251 incident T2D cases and a random sample of 694 participants (641 non-cases and 53 overlapping cases) without T2D at baseline (median follow-up: 3.8 years). Metabolites were semi-quantitatively profiled with LC-MS/MS. Cox regression analysis revealed that high plasma allantoin levels, including allantoin-to-uric acid ratio and high xanthine-to-hypoxanthine ratio were inversely and positively associated with T2D risk, respectively, independently of classical risk factors. Elevated plasma xanthine and inosine levels were associated with a higher T2D risk in homozygous carriers of the TCF7L2-rs7903146 T-allele. The potential mechanisms linking the aforementioned purine metabolites and T2D risk must be also further investigated. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41598-019-39441-6 | - |
dc.relation.ispartof | Scientific Reports, 2019, vol. 9, p. 2892 | - |
dc.relation.uri | https://doi.org/10.1038/s41598-019-39441-6 | - |
dc.rights | cc-by (c) Papandreou, Christopher et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Metabòlits | - |
dc.subject.classification | Diabetis no-insulinodependent | - |
dc.subject.classification | Polimorfisme (Cristal·lografia) | - |
dc.subject.other | Metabolites | - |
dc.subject.other | Non-insulin-dependent diabetes | - |
dc.subject.other | Polymorphism (Crystallography) | - |
dc.title | Metabolites related to purine catabolism and risk of type 2 diabetes incidence; modifying effects of the TCF7L2-rs7903146 polymorphism. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 687759 | - |
dc.date.updated | 2020-05-26T21:31:27Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 30814579 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
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File | Description | Size | Format | |
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687759.pdf | 1.29 MB | Adobe PDF | View/Open |
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