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|Title:||Epigenetic modification of the pentose phosphate pathway and the IGF-axis in women with gestational diabetes mellitus|
Crowther, Nigel J.
Norris, Shane A.
Rabionet Janssen, Raquel
Estivill, Xavier, 1955-
|Keywords:||Diabetis en l'embaràs|
Diabetes in pregnancy
|Abstract:||Aim: Gestational diabetes mellitus (GDM) has been linked with adverse long-term health outcomes for the fetus and mother. These effects may be mediated by epigenetic modifications. Materials & methods: Genome-wide RNA sequencing was performed in placental tissue and maternal blood in six GDM and six non-GDM pregnancies. Promoter region DNA methylation was examined for selected genes and correlated with gene expression to examine an epigenetic modulator mechanism. Results: Reductions of mRNA expression and increases in promoter methylation were observed for G6PD in GDM women, and for genes encoding IGF-binding proteins in GDM-exposed placenta. Conclusion: GDM involves epigenetic attenuation of G6PD, which may lead to hyperglycemia and oxidative stress, and the IGF-axis, which may modulate fetal macrosomia.|
|Note:||Versió postprint del document publicat a: https://doi.org/10.2217/epi-2018-0206|
|It is part of:||Epigenomics, 2019, vol. 11, num. 12|
|Appears in Collections:||Articles publicats en revistes (Genètica, Microbiologia i Estadística)|
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