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http://hdl.handle.net/2445/162875| Title: | Polymorphism of Sildenafil: A New Metastable Desolvate |
| Author: | Barbas Cañero, Rafael Font Bardia, Ma. Mercedes Prohens López, Rafael |
| Keywords: | Estructura cristal·lina (Sòlids) Molècules Dissolvents Layer structure (Solids) Molecules Solvents |
| Issue Date: | 2018 |
| Publisher: | American Chemical Society |
| Abstract: | A new anhydrous polymorph of the free base of sildenafil and two solvates (acetonitrile and propanenitrile) have been discovered and fully characterized. The new polymorph can be considered a desolvate of the acetonitrile solvate and is related to the most stable form I by morphotropism. The new polymorph can only be obtained by desolvation of the acetonitrile solvate. Thus, this study is a new example of the importance of this multicomponent family of solid forms in the discovery of new polymorphs of active pharmaceutical ingredients. |
| Note: | Versió postprint del document publicat a: https://doi.org/10.1021/acs.cgd.8b00683 |
| It is part of: | Crystal Growth & Design, 2018, vol. 18, num. 7, p. 3740-3746 |
| URI: | http://hdl.handle.net/2445/162875 |
| Related resource: | https://doi.org/10.1021/acs.cgd.8b00683 |
| ISSN: | 1528-7483 |
| Appears in Collections: | Articles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 693055.pdf | 2.51 MB | Adobe PDF | View/Open |
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