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http://hdl.handle.net/2445/162875Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Barbas Cañero, Rafael | - |
| dc.contributor.author | Font Bardia, Ma. Mercedes | - |
| dc.contributor.author | Prohens López, Rafael | - |
| dc.date.accessioned | 2020-05-28T16:43:10Z | - |
| dc.date.available | 2020-05-28T16:43:10Z | - |
| dc.date.issued | 2018 | - |
| dc.identifier.issn | 1528-7483 | - |
| dc.identifier.uri | http://hdl.handle.net/2445/162875 | - |
| dc.description.abstract | A new anhydrous polymorph of the free base of sildenafil and two solvates (acetonitrile and propanenitrile) have been discovered and fully characterized. The new polymorph can be considered a desolvate of the acetonitrile solvate and is related to the most stable form I by morphotropism. The new polymorph can only be obtained by desolvation of the acetonitrile solvate. Thus, this study is a new example of the importance of this multicomponent family of solid forms in the discovery of new polymorphs of active pharmaceutical ingredients. | - |
| dc.format.extent | 27 p. | - |
| dc.format.mimetype | application/pdf | - |
| dc.language.iso | eng | - |
| dc.publisher | American Chemical Society | - |
| dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1021/acs.cgd.8b00683 | - |
| dc.relation.ispartof | Crystal Growth & Design, 2018, vol. 18, num. 7, p. 3740-3746 | - |
| dc.relation.uri | https://doi.org/10.1021/acs.cgd.8b00683 | - |
| dc.rights | (c) American Chemical Society , 2018 | - |
| dc.source | Articles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada) | - |
| dc.subject.classification | Estructura cristal·lina (Sòlids) | - |
| dc.subject.classification | Molècules | - |
| dc.subject.classification | Dissolvents | - |
| dc.subject.other | Layer structure (Solids) | - |
| dc.subject.other | Molecules | - |
| dc.subject.other | Solvents | - |
| dc.title | Polymorphism of Sildenafil: A New Metastable Desolvate | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/acceptedVersion | - |
| dc.identifier.idgrec | 693055 | - |
| dc.date.updated | 2020-05-28T16:43:10Z | - |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
| Appears in Collections: | Articles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada) | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 693055.pdf | 2.51 MB | Adobe PDF | View/Open |
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