Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/163029
Title: | DNA delivery via cationic solid lipid nanoparticles (SLNs) |
Author: | Carrillo Sánchez, Carolina Sánchez Hernández, Noemí García Montoya, Encarna Pérez Lozano, Pilar Ticó Grau, Josep R. Suñé i Negre, Josep M. (Josep Maria) Suñé, Carlos Miñarro Carmona, Montserrat |
Keywords: | Dispositius d'administració de medicaments Nanopartícules Teràpia genètica Biomolècules Drug delivery devices Nanoparticles Gene therapy Biomolecules |
Issue Date: | 27-Feb-2013 |
Publisher: | Elsevier B.V. |
Abstract: | In recent years the use of solid lipid nanoparticles (SLNs) as transport systems for the delivery of drugs and biomolecules has become particularly important. The use of cationic SLNs developed by the technique of microemulsion, which are complexed with DNA in order to study their application as non-viral vectors in gene therapy, is reported. The nanoparticles are characterized by scanning electron microscopy and transmission electron microscopy (SEM and TEM), atomic force microscopy (AFM) and differential scanning calorimetry (DSC). Furthermore, the process of lyophilization of the samples and their stability was studied. The nanoparticles obtained presented a particle size of 340 nm with a positive surface charge of 44 mV and the capability of forming lipoplexes with DNA plasmids was stated. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1016/j.ejps.2013.02.011 |
It is part of: | European Journal of Pharmaceutical Sciences, 2013, vol. 49, num. 2, p. 157-165 |
URI: | http://hdl.handle.net/2445/163029 |
Related resource: | https://doi.org/10.1016/j.ejps.2013.02.011 |
ISSN: | 0928-0987 |
Appears in Collections: | Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) |
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