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http://hdl.handle.net/2445/163111
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DC Field | Value | Language |
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dc.contributor.author | Sala Llonch, Roser | - |
dc.contributor.author | Idland, Ane Victoria | - |
dc.contributor.author | Borza, Tom | - |
dc.contributor.author | Watne, Leiv Otto | - |
dc.contributor.author | Wyller, Torgeir Bruun | - |
dc.contributor.author | Brækhus, Anne | - |
dc.contributor.author | Zetterberg, Henrik | - |
dc.contributor.author | Blennow, Kaj | - |
dc.contributor.author | Walhovd, Kristine Beate | - |
dc.contributor.author | Fjell, Anders Martin | - |
dc.date.accessioned | 2020-05-29T15:04:41Z | - |
dc.date.available | 2020-05-29T15:04:41Z | - |
dc.date.issued | 2017-06-05 | - |
dc.identifier.issn | 1387-2877 | - |
dc.identifier.uri | http://hdl.handle.net/2445/163111 | - |
dc.description.abstract | Amyloid deposition occurs in aging, even in individuals free from cognitive symptoms, and is often interpreted as preclinical Alzheimer's disease (AD) pathophysiology. YKL-40 is a marker of neuroinflammation, being increased in AD, and hypothesized to interact with amyloid-B (AB ) in causing cognitive decline early in the cascade of AD pathophysiology. Whether and how A and YKL-40 affect brain and cognitive changes in cognitively healthy older adults is still unknown. We studied 89 participants (mean age: 73.1 years) with cerebrospinal fluid samples at baseline, and both MRI and cognitive assessments from two time-points separated by two years. We tested how baseline levels of AB 42 and YKL-40 correlated with changes in cortical thickness and cognition. Thickness change correlated with AB 42 only in AB 42+ participants (<600 pg/mL, n = 27) in the left motor and premotor cortices. AB 42 was unrelated to cognitive change. Increased YKL-40 was associated with less preservation of scores on the animal naming test in the total sample (r = -0.28, p = 0.012) and less preservation of a score reflecting global cognitive function for AB 42+ participants (r = -0.58, p = 0.004). Our results suggest a role for inflammation in brain atrophy and cognitive changes in cognitively normal older adults, which partly depended on AB accumulation. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | IOS Press | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3233/JAD-161146 | - |
dc.relation.ispartof | Journal of Alzheimer's Disease, 2017, vol. 58, num. 3, p. 829-840 | - |
dc.relation.uri | https://doi.org/10.3233/JAD-161146 | - |
dc.rights | (c) Sala Llonch, Roser et al., 2017 | - |
dc.source | Articles publicats en revistes (Biomedicina) | - |
dc.subject.classification | Envelliment | - |
dc.subject.classification | Envelliment cerebral | - |
dc.subject.classification | Inflamació | - |
dc.subject.other | Aging | - |
dc.subject.other | Aging brain | - |
dc.subject.other | Inflammation | - |
dc.title | Inflammation, amyloid, and atrophy in the aging brain: relationships with longitudinal changes in cognition | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 678213 | - |
dc.date.updated | 2020-05-29T15:04:41Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28505968 | - |
Appears in Collections: | Articles publicats en revistes (Biomedicina) |
Files in This Item:
File | Description | Size | Format | |
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678213.pdf | 798.81 kB | Adobe PDF | View/Open |
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