Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/163157
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sala Llonch, Roser | - |
dc.contributor.author | Fortea Ormaechea, Juan | - |
dc.contributor.author | Bartrés Faz, David | - |
dc.contributor.author | Bosch, Beatriz | - |
dc.contributor.author | Lladó Plarrumaní, Albert | - |
dc.contributor.author | Peña-Gómez, Cleofé | - |
dc.contributor.author | Antonell, Anna | - |
dc.contributor.author | Castellanos Pinedo, Fernando | - |
dc.contributor.author | Bargalló Alabart, Núria | - |
dc.contributor.author | Molinuevo, José Luis | - |
dc.contributor.author | Sánchez del Valle Díaz, Raquel | - |
dc.date.accessioned | 2020-05-29T15:27:53Z | - |
dc.date.available | 2020-05-29T15:27:53Z | - |
dc.date.issued | 2013-06-04 | - |
dc.identifier.issn | 1387-2877 | - |
dc.identifier.uri | http://hdl.handle.net/2445/163157 | - |
dc.description.abstract | PSEN1 mutations are the most frequent cause of familial Alzheimer's disease and show nearly full penetrance. Here we studied alterations in brain function in a cohort of 19 PSEN1 mutation carriers: 8 symptomatic (SMC) and 11 asymptomatic (AMC). Asymptomatic carriers were, on average, 12 years younger than the predicted age of disease onset. Thirteen healthy subjects were used as a control group (CTR). Subjects underwent a 10-min resting-state functional magnetic resonance imaging (fMRI) scan and also performed a visual encoding task. The analysis of resting-state fMRI data revealed alterations in the default mode network, with increased frontal connectivity and reduced posterior connectivity in AMC and decreased frontal and increased posterior connectivity in SMC. During task-related fMRI, SMC showed reduced activity in regions of the left occipital and left prefrontal cortices, while both AMC and SMC showed increased activity in a region within the precuneus/posterior cingulate, all as compared to CTR. Our findings suggest that fMRI can detect evolving changes in brain mechanisms in PSEN1 mutation carriers and support the use of this technique as a biomarker in Alzheimer's disease, even before the appearance of clinical symptoms. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | IOS Press | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3233/JAD-130062 | - |
dc.relation.ispartof | Journal of Alzheimer's Disease, 2013, vol. 36, num. 1, p. 165-175 | - |
dc.relation.uri | https://doi.org/10.3233/JAD-130062 | - |
dc.rights | (c) Sala Llonch, Roser et al., 2013 | - |
dc.source | Articles publicats en revistes (Biomedicina) | - |
dc.subject.classification | Cervell | - |
dc.subject.classification | Mutació (Biologia) | - |
dc.subject.classification | Imatges per ressonància magnètica | - |
dc.subject.classification | Malaltia d'Alzheimer | - |
dc.subject.other | Brain | - |
dc.subject.other | Mutation (Biology) | - |
dc.subject.other | Magnetic resonance imaging | - |
dc.subject.other | Alzheimer's disease | - |
dc.title | Evolving brain functional abnormalities in PSEN1 mutation carriers: A resting and visual encoding fMRI study | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 621309 | - |
dc.date.updated | 2020-05-29T15:27:53Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 23579331 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (Biomedicina) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
621309.pdf | 436.9 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.