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http://hdl.handle.net/2445/163163
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DC Field | Value | Language |
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dc.contributor.author | Mayoral Peñalva, Maria | - |
dc.contributor.author | Niñerola Baizán, Aida | - |
dc.contributor.author | Marti Fuster, Berta | - |
dc.contributor.author | Donaire Pedraza, Antonio Jesús | - |
dc.contributor.author | Perissinotti, Andrés | - |
dc.contributor.author | Rumià, Jordi | - |
dc.contributor.author | Bargalló Alabart, Núria | - |
dc.contributor.author | Sala Llonch, Roser | - |
dc.contributor.author | Pavía Segura, Javier | - |
dc.contributor.author | Ros Puig, Domènec | - |
dc.contributor.author | Carreño, Mar | - |
dc.contributor.author | Pons Pons, Francisca | - |
dc.contributor.author | Setoain Perego, Xavier | - |
dc.date.accessioned | 2020-05-29T16:52:49Z | - |
dc.date.available | 2020-05-29T16:52:49Z | - |
dc.date.issued | 2019-04-17 | - |
dc.identifier.issn | 1664-2295 | - |
dc.identifier.uri | http://hdl.handle.net/2445/163163 | - |
dc.description.abstract | Introduction: [18F]fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) is part of the regular preoperative work-up in medically refractory epilepsy. As a complement to visual evaluation of PET, statistical parametric maps can help in the detection of the epileptogenic zone (EZ). However, software packages currently available are time-consuming and little intuitive for physicians. We develop a user-friendly software (referred as PET-analysis) for EZ localization in PET studies that allows dynamic real-time statistical parametric analysis. To evaluate its performance, the outcome of PET-analysis was compared with the results obtained by visual assessment and Statistical Parametric Mapping (SPM). Methods: Thirty patients with medically refractory epilepsy who underwent presurgical 18F-FDG PET with good post-operative outcomes were included. The 18F-FDG PET studies were evaluated by visual assessment, with SPM8 and PET-analysis. In SPM, parametric T-maps were thresholded at corrected p < 0.05 and cluster size k = 50 and at uncorrected p < 0.001 and k = 100 (the most used parameters in the literature). Since PET-analysis rapidly processes different threshold combinations, T-maps were thresholded with multiple p-value and different clusters sizes. The presurgical EZ identified by visual assessment, SPM and PET-analysis was compared to the confirmed EZ according to post-surgical follow-up. Results: PET-analysis obtained 66.7% (20/30) of correctly localizing studies, comparable to the 70.0% (21/30) achieved by visual assessment and significantly higher (p < 0.05) than that obtained with the SPM threshold p < 0.001/k = 100, of 36.7% (11/30). Only one study was positive, albeit non-localizing, with the SPM threshold corrected p < 0.05/k = 50. Concordance was substantial for PET-analysis (κ = 0.643) and visual interpretation (κ = 0.622), being fair for SPM (κ = 0.242). Conclusion: Compared to SPM with the fixed standard parameters, PET-analysis may be superior in EZ localization with its easy and rapid processing of different threshold combinations. The results of this initial proof-of-concept study validate the clinical use of PET-analysis as a robust objective complementary tool to visual assessment for EZ localization. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Frontiers Media | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3389/fneur.2019.00380 | - |
dc.relation.ispartof | Frontiers In Neurology, 2019, vol. 10, num. 380 | - |
dc.relation.uri | https://doi.org/10.3389/fneur.2019.00380 | - |
dc.rights | cc-by (c) Mayoral Peñalva, Maria et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Biomedicina) | - |
dc.subject.classification | Tomografia computada per emissió de fotó simple | - |
dc.subject.classification | Epilèpsia | - |
dc.subject.classification | Neurocirurgia | - |
dc.subject.other | Single-photon emission computed tomography | - |
dc.subject.other | Epilepsy | - |
dc.subject.other | Neurosurgery | - |
dc.title | Epileptogenic zone localization with (18)FDG PET using a new dynamic parametric analysis | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 691637 | - |
dc.date.updated | 2020-05-29T16:52:49Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31057476 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Biomedicina) |
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691637.pdf | 1.88 MB | Adobe PDF | View/Open |
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