Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/163166
Title: White Matter/Gray Matter Contrast Changes in Chronic and Diffuse Traumatic brain Injury
Author: Palacios, Eva M.
Sala Llonch, Roser
Junqué i Plaja, Carme, 1955-
Roig-Rovira, Teresa
Tormos, Jose Maria
Bargalló Alabart, Núria​
Vendrell i Gómez, Pere
Keywords: Traumatismes cranials
Trastorns de la cognició
Imatges per ressonància magnètica
Skull injuries
Cognition disorders
Magnetic resonance imaging
Issue Date: 1-Oct-2013
Publisher: Mary Ann Liebert
Abstract: Signal-intensity contrast of T1-weighted magnetic resonance imaging scans has been associated with tissue integrity and reported as a sign of neurodegenerative changes in diseases such as Alzheimer's disease. After severe traumatic brain injury (TBI), progressive structural changes occur in white (WM) and gray matter (GM). In the current study, we assessed the signal-intensity contrast of GM and WM in patients with diffuse TBI in the chronic stage to (1) characterize the regional pattern of WM/GM changes in intensity contrast associated with traumatic axonal injury, (2) evaluate possible associations between this measure and diffusion tensor image (DTI)/fractional anisotropy (FA) for detecting WM damage, and (3) investigate the correlates of both measures with cognitive outcomes. Structural T1 scans were processed with FreeSurfer software to identify the boundary and calculate the WM/GM contrast maps. DTIs were processed with the FMRIB software library to obtain FA maps. The WM/GM contrast in TBI patients showed a pattern of reduction in almost all of the brain, except the visual and motor primary regions. Global FA values obtained from DTI correlated with the intensity contrast of all associative cerebral regions. WM/GM contrast correlated with memory functions, whereas FA global values correlated with tests measuring memory and mental processing speed. In conclusion, tissue-contrast intensity is a very sensitive measure for detecting structural brain damage in chronic, severe and diffuse TBI, but is less sensitive than FA for reflecting neuropsychological sequelae, such as impaired mental processing speed.
Note: Reproducció del document publicat a: https://doi.org/10.1089/neu.2012.2836
It is part of: Journal of Neurotrauma, 2013, vol. 30, num. 23, p. 1991-1994
URI: http://hdl.handle.net/2445/163166
Related resource: https://doi.org/10.1089/neu.2012.2836
ISSN: 0897-7151
Appears in Collections:Articles publicats en revistes (Biomedicina)

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