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Title: Light-induced regulation of ligand-gated channel activity
Author: Bregestovski, Piotr
Maleeva, Galyna
Gorostiza Langa, Pablo Ignacio
Keywords: Biologia molecular
Receptors neurals
Molecular biology
Neural receptor
Issue Date: 31-Aug-2017
Publisher: John Wiley & Sons
Abstract: The control of ligand-gated receptors with light using photochromic compounds has evolved from the first handcrafted examples to accurate, engineered receptors, whose development is supported by rational design, high-resolution protein structures, comparative pharmacology and molecular biology manipulations. Photoswitchable regulators have been designed and characterized for a large number of ligand-gated receptors in the mammalian nervous system, including nicotinic acetylcholine, glutamate and GABA receptors. They provide a well-equipped toolbox to investigate synaptic and neuronal circuits in all-optical experiments. This focused review discusses the design and properties of these photoswitches, their applications and shortcomings and future perspectives in the field.
Note: Versió postprint del document publicat a:
It is part of: British Journal of Pharmacology, 2018, vol. 175, num. 11, p. 1892-1902
Related resource:
ISSN: 0007-1188
Appears in Collections:Publicacions de projectes de recerca finançats per la UE
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

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