Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/163519
Title: | Light-induced regulation of ligand-gated channel activity |
Author: | Bregestovski, Piotr Maleeva, Galyna Gorostiza Langa, Pablo Ignacio |
Keywords: | Biologia molecular Receptors neurals Molecular biology Neural receptor |
Issue Date: | 31-Aug-2017 |
Publisher: | John Wiley & Sons |
Abstract: | The control of ligand-gated receptors with light using photochromic compounds has evolved from the first handcrafted examples to accurate, engineered receptors, whose development is supported by rational design, high-resolution protein structures, comparative pharmacology and molecular biology manipulations. Photoswitchable regulators have been designed and characterized for a large number of ligand-gated receptors in the mammalian nervous system, including nicotinic acetylcholine, glutamate and GABA receptors. They provide a well-equipped toolbox to investigate synaptic and neuronal circuits in all-optical experiments. This focused review discusses the design and properties of these photoswitches, their applications and shortcomings and future perspectives in the field. |
Note: | Versió postprint del document publicat a: http://dx.doi.org/10.1111/bph.14022 |
It is part of: | British Journal of Pharmacology, 2018, vol. 175, num. 11, p. 1892-1902 |
URI: | http://hdl.handle.net/2445/163519 |
Related resource: | http://dx.doi.org/10.1111/bph.14022 |
ISSN: | 0007-1188 |
Appears in Collections: | Publicacions de projectes de recerca finançats per la UE Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) |
Files in This Item:
File | Description | Size | Format | |
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L01_2018_British Journal of Pharmacology_175_1892_OA.pdf | 325.71 kB | Adobe PDF | View/Open |
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